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Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 1: in vitro modeling of vericiguat.

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Title: Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 1: in vitro modeling of vericiguat.
Authors: Vrenken P; Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, Greece; Bayer AG, Pharmacometrics/Modeling and Simulation, Model-Informed Drug Development, Leverkusen, Germany., Vertzoni M; Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, Greece., Frechen S; Bayer AG, Pharmacometrics/Modeling and Simulation, Model-Informed Drug Development, Leverkusen, Germany., Solodenko J; Bayer AG, Pharmacometrics/Modeling and Simulation, Model-Informed Drug Development, Leverkusen, Germany., Meyer M; Bayer AG, Pharmacometrics/Modeling and Simulation, Model-Informed Drug Development, Leverkusen, Germany., Muenster U; Bayer AG, Research and Development, Pharmaceutical Sciences, Advanced Drug Delivery, Wuppertal, Germany., Dallmann A; Bayer HealthCare SAS, Lille, France, on Behalf of Bayer AG, Model-Informed Drug Development, 1 Rue Claude Bernard, Leverkusen, Lille 59000, Germany. Electronic address: andre.dallmann@bayer.com.
Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Sep 01; Vol. 212, pp. 107164. Date of Electronic Publication: 2025 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0720
DOI:10.1016/j.ejps.2025.107164