Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.

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Title: Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.
Authors: Jiang Y; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016., Sachdeva K; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016., Goulbourne CN; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Berg MJ; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Peddy J; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Stavrides PH; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Pensalfini A; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Pawlik M; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Malampati S; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Whyte L; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Basavarajappa BS; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016., Subbanna S; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Bleiwas C; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Smiley JF; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962, and., Mathews PM; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Departments of Cell Biology, New York University Grossman School of Medicine, New York, New York 10016., Nixon RA; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962 Ralph.Nixon@nki.rfmh.org.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Departments of Cell Biology, New York University Grossman School of Medicine, New York, New York 10016.; Neuroscience Institute, New York University Grossman School of Medicine, New York, New York 10016.
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Jul 16; Vol. 45 (29). Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.<br /><searchLink fieldCode="AU" term="%22Sachdeva+K%22">Sachdeva K</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.<br /><searchLink fieldCode="AU" term="%22Goulbourne+CN%22">Goulbourne CN</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Berg+MJ%22">Berg MJ</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Peddy+J%22">Peddy J</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Stavrides+PH%22">Stavrides PH</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Pensalfini+A%22">Pensalfini A</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Pawlik+M%22">Pawlik M</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Malampati+S%22">Malampati S</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Whyte+L%22">Whyte L</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Basavarajappa+BS%22">Basavarajappa BS</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.<br /><searchLink fieldCode="AU" term="%22Subbanna+S%22">Subbanna S</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Bleiwas+C%22">Bleiwas C</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.<br /><searchLink fieldCode="AU" term="%22Smiley+JF%22">Smiley JF</searchLink>; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962, and.<br /><searchLink fieldCode="AU" term="%22Mathews+PM%22">Mathews PM</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Departments of Cell Biology, New York University Grossman School of Medicine, New York, New York 10016.<br /><searchLink fieldCode="AU" term="%22Nixon+RA%22">Nixon RA</searchLink>; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962 Ralph.Nixon@nki.rfmh.org.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Departments of Cell Biology, New York University Grossman School of Medicine, New York, New York 10016.; Neuroscience Institute, New York University Grossman School of Medicine, New York, New York 10016.
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        Value: 10.1523/JNEUROSCI.2331-24.2025
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        Text: English
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      – TitleFull: Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.
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