Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.

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Title:	Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.
Authors:	Jiang Y; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016., Sachdeva K; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016., Goulbourne CN; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Berg MJ; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Peddy J; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Stavrides PH; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Pensalfini A; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Pawlik M; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Malampati S; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Whyte L; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Basavarajappa BS; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016., Subbanna S; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Bleiwas C; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962., Smiley JF; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962, and., Mathews PM; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Departments of Cell Biology, New York University Grossman School of Medicine, New York, New York 10016., Nixon RA; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962 Ralph.Nixon@nki.rfmh.org.; Department of Psychiatry, New York University Grossman School of Medicine, New York, New York 10016.; Departments of Cell Biology, New York University Grossman School of Medicine, New York, New York 10016.; Neuroscience Institute, New York University Grossman School of Medicine, New York, New York 10016.
Source:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Jul 16; Vol. 45 (29). Date of Electronic Publication: 2025 Jul 16.
Publication Type:	Journal Article; Research Support, N.I.H., Extramural
Journal Info:	Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	1529-2401
DOI:	10.1523/JNEUROSCI.2331-24.2025