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Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells.

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Title: Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells.
Authors: Petrozziello E; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Sayed A; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Freitas JA; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Federle C; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Nedjic J; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Ravens S; Institute of Immunology, Hannover Medical School, Hannover, Germany., Akçabozan B; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Schulz AM; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan and TUM Center for Infection Prevention, Technical University of Munich, Freising, Germany.; Onkologisches Zentrum Freising MVZ, Freising, Germany., Zehn D; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan and TUM Center for Infection Prevention, Technical University of Munich, Freising, Germany., Schmidt-Supprian M; Institute for Experimental Hematology, Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany., Obst R; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Prinz I; Institute of Immunology, Hannover Medical School, Hannover, Germany.; Institute of Systems Immunology, Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Verdoes M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Kisielow J; Institute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.; Repertoire Immune Medicines, Schlieren, Switzerland., Reinheckel T; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Straub T; Bioinformatics Unit, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany., Daley SR; Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Klein L; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany. ludger.klein@med.uni-muenchen.de.
Source: Nature immunology [Nat Immunol] 2025 Jul; Vol. 26 (7), pp. 1127-1138. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4<superscript>+</superscript> T cells.
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  Data: <searchLink fieldCode="AU" term="%22Petrozziello+E%22">Petrozziello E</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Sayed+A%22">Sayed A</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Freitas+JA%22">Freitas JA</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Federle+C%22">Federle C</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Nedjic+J%22">Nedjic J</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Ravens+S%22">Ravens S</searchLink>; Institute of Immunology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Akçabozan+B%22">Akçabozan B</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Schulz+AM%22">Schulz AM</searchLink>; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan and TUM Center for Infection Prevention, Technical University of Munich, Freising, Germany.; Onkologisches Zentrum Freising MVZ, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Zehn+D%22">Zehn D</searchLink>; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan and TUM Center for Infection Prevention, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt-Supprian+M%22">Schmidt-Supprian M</searchLink>; Institute for Experimental Hematology, Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Obst+R%22">Obst R</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Prinz+I%22">Prinz I</searchLink>; Institute of Immunology, Hannover Medical School, Hannover, Germany.; Institute of Systems Immunology, Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Verdoes+M%22">Verdoes M</searchLink>; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kisielow+J%22">Kisielow J</searchLink>; Institute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.; Repertoire Immune Medicines, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Reinheckel+T%22">Reinheckel T</searchLink>; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Straub+T%22">Straub T</searchLink>; Bioinformatics Unit, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Daley+SR%22">Daley SR</searchLink>; Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Klein+L%22">Klein L</searchLink>; Institute for Immunology, Biomedical Center, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany. ludger.klein@med.uni-muenchen.de.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2025 Jul; Vol. 26 (7), pp. 1127-1138. <i>Date of Electronic Publication: </i>2025 Jun 13.
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