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Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics.

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Title: Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics.
Authors: Liu K; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., Wang Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Li J; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Zhou J; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., da Silva AMG; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Suñer C; Sexually Transmitted Infections and Skin Neglected Tropical Diseases Section, Fight Infectious Diseases Foundation, Hospital Germans Trias i Pujol, Badalona, Spain., Dai Z; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Schraauwen R; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Boor PPC; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Ober-Vliegen K; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., van den Hil F; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands., Offermans DM; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Tsikari T; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands., Ayada I; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., van Royen ME; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Verstegen MMA; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., Wang Y; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Orkin CM; SHARE Collaborative, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Janssen HLA; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.; Toronto Center for Liver Disease, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada., Orlova VV; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands., Li P; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Mitjà O; Sexually Transmitted Infections and Skin Neglected Tropical Diseases Section, Fight Infectious Diseases Foundation, Hospital Germans Trias i Pujol, Badalona, Spain., Duarte-Neto AN; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., van der Laan LJW; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands. l.vanderlaan@erasmusmc.nl., Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. q.pan@erasmusmc.nl.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Nov; Vol. 9 (11), pp. 1848-1868. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics.
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  Data: <searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22da+Silva+AMG%22">da Silva AMG</searchLink>; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Suñer+C%22">Suñer C</searchLink>; Sexually Transmitted Infections and Skin Neglected Tropical Diseases Section, Fight Infectious Diseases Foundation, Hospital Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Dai+Z%22">Dai Z</searchLink>; School of Medicine, Southern University of Science and Technology, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Schraauwen+R%22">Schraauwen R</searchLink>; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boor+PPC%22">Boor PPC</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ober-Vliegen+K%22">Ober-Vliegen K</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Hil+F%22">van den Hil F</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Offermans+DM%22">Offermans DM</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tsikari+T%22">Tsikari T</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ayada+I%22">Ayada I</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Peppelenbosch+MP%22">Peppelenbosch MP</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Royen+ME%22">van Royen ME</searchLink>; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verstegen+MMA%22">Verstegen MMA</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; School of Medicine, Southern University of Science and Technology, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Orkin+CM%22">Orkin CM</searchLink>; SHARE Collaborative, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Janssen+HLA%22">Janssen HLA</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.; Toronto Center for Liver Disease, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Orlova+VV%22">Orlova VV</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mitjà+O%22">Mitjà O</searchLink>; Sexually Transmitted Infections and Skin Neglected Tropical Diseases Section, Fight Infectious Diseases Foundation, Hospital Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Duarte-Neto+AN%22">Duarte-Neto AN</searchLink>; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22van+der+Laan+LJW%22">van der Laan LJW</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands. l.vanderlaan@erasmusmc.nl.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. q.pan@erasmusmc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2025 Nov; Vol. 9 (11), pp. 1848-1868. <i>Date of Electronic Publication: </i>2025 Jun 13.
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