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Radiosynthesis of [131I]I-Hesperidin: Optimization, physicochemical profiling, and computational insights for targeted radiopharmaceuticals.

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Title: Radiosynthesis of [131I]I-Hesperidin: Optimization, physicochemical profiling, and computational insights for targeted radiopharmaceuticals.
Authors: Munir M; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia; School of Biomedical Sciences, Faculty of Health Medicine and Behavioural Sciences, the University of Queensland, Australia., Forentin AM; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia., Febrian MB; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia., Fakih TM; Department of Pharmaceutical Analysis and Medicinal Chemistry, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Sumedang, 45363, Indonesia; Department of Pharmacy, Universitas Islam Bandung, Jl. Ranggagading, Bandung, 40116, Indonesia., Utomo RY; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia., Aries A; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia; Research Collaboration Center for Theranostic Radiopharmaceuticals, Jl Ir. Soekarno KM 21, Jatinangor, 45363, Indonesia., Lestari W; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia., Meiyanto E; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia., Muchtaridi M; Department of Pharmaceutical Analysis and Medicinal Chemistry, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Sumedang, 45363, Indonesia; Research Collaboration Center for Theranostic Radiopharmaceuticals, Jl Ir. Soekarno KM 21, Jatinangor, 45363, Indonesia., Septisetyani EP; Research Center for Genetic Engineering, National Research and Innovation Agency, KST Soekarno, Jl. Raya Bogor KM 46, Cibinong, Bogor, 16911, Indonesia., Astirin OP; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Sebelas Maret, Surakarta, 57126, Indonesia., Syaifudin M; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia; Research Collaboration Center for Theranostic Radiopharmaceuticals, Jl Ir. Soekarno KM 21, Jatinangor, 45363, Indonesia. Electronic address: mukh002@brin.go.id.
Source: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2025 Nov; Vol. 225, pp. 111977. Date of Electronic Publication: 2025 Jun 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 9306253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9800 (Electronic) Linking ISSN: 09698043 NLM ISO Abbreviation: Appl Radiat Isot Subsets: MEDLINE
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  Data: Radiosynthesis of [<superscript>131</superscript>I]I-Hesperidin: Optimization, physicochemical profiling, and computational insights for targeted radiopharmaceuticals.
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  Data: <searchLink fieldCode="AU" term="%22Munir+M%22">Munir M</searchLink>; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia; School of Biomedical Sciences, Faculty of Health Medicine and Behavioural Sciences, the University of Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Forentin+AM%22">Forentin AM</searchLink>; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia.<br /><searchLink fieldCode="AU" term="%22Febrian+MB%22">Febrian MB</searchLink>; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia.<br /><searchLink fieldCode="AU" term="%22Fakih+TM%22">Fakih TM</searchLink>; Department of Pharmaceutical Analysis and Medicinal Chemistry, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Sumedang, 45363, Indonesia; Department of Pharmacy, Universitas Islam Bandung, Jl. Ranggagading, Bandung, 40116, Indonesia.<br /><searchLink fieldCode="AU" term="%22Utomo+RY%22">Utomo RY</searchLink>; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia.<br /><searchLink fieldCode="AU" term="%22Aries+A%22">Aries A</searchLink>; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia; Research Collaboration Center for Theranostic Radiopharmaceuticals, Jl Ir. Soekarno KM 21, Jatinangor, 45363, Indonesia.<br /><searchLink fieldCode="AU" term="%22Lestari+W%22">Lestari W</searchLink>; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia.<br /><searchLink fieldCode="AU" term="%22Meiyanto+E%22">Meiyanto E</searchLink>; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia.<br /><searchLink fieldCode="AU" term="%22Muchtaridi+M%22">Muchtaridi M</searchLink>; Department of Pharmaceutical Analysis and Medicinal Chemistry, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Sumedang, 45363, Indonesia; Research Collaboration Center for Theranostic Radiopharmaceuticals, Jl Ir. Soekarno KM 21, Jatinangor, 45363, Indonesia.<br /><searchLink fieldCode="AU" term="%22Septisetyani+EP%22">Septisetyani EP</searchLink>; Research Center for Genetic Engineering, National Research and Innovation Agency, KST Soekarno, Jl. Raya Bogor KM 46, Cibinong, Bogor, 16911, Indonesia.<br /><searchLink fieldCode="AU" term="%22Astirin+OP%22">Astirin OP</searchLink>; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Sebelas Maret, Surakarta, 57126, Indonesia.<br /><searchLink fieldCode="AU" term="%22Syaifudin+M%22">Syaifudin M</searchLink>; Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency (BRIN), Building 71, Kawasan Puspiptek, Setu, Tangerang Selatan, Banten, 15310, Indonesia; Research Collaboration Center for Theranostic Radiopharmaceuticals, Jl Ir. Soekarno KM 21, Jatinangor, 45363, Indonesia. Electronic address: mukh002@brin.go.id.
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        Value: 10.1016/j.apradiso.2025.111977
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