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Triple therapy vs dual inhaler therapy for moderate-to-severe asthma: An updated systematic review and meta-analysis.

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Title: Triple therapy vs dual inhaler therapy for moderate-to-severe asthma: An updated systematic review and meta-analysis.
Authors: Rayner DG; Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada., Bakaa L; Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada; Harvard TH Chan School of Public Health, Harvard University, Boston, Massachusetts., Hoyte F; Department of Medicine, National Jewish Health, Denver, Colorado., Perry TT; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Rivera-Spoljaric K; Division of Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri., Sumino K; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri., Chipps B; Capital Allergy and Respiratory Disease Center, Sacramento, California., Oppenheimer J; Department of Internal Medicine, University of Medicine and Dentistry of New Jersey/Rutgers New Jersey Medical School, Newark, New Jersey., Nyenhuis SM; Department of Pediatrics, The University of Chicago, Chicago, Illinois., Israel E; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., McCabe E; Hunter-Bellevue School of Nursing, Hunter College, New York, New York., O'Byrne PM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Shade LE; Department of Family and Community Medicine Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Press VG; Department of Medicine, The University of Chicago, Chicago, Illinois., Guyatt GH; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Rangel S; Los Angeles General Medical Center, Los Angeles, California., Sue-Wah-Sing D; Patient and Caregiver Partner., Hall L; Patient and Caregiver Partner., Orr H; Patient and Caregiver Partner., Melendez A; Patient and Caregiver Partner., Winders T; Global Allergy and Airways Patient Platform, Vienna, Austria., Gardner DD; Allergy and Asthma Network, Fairfax, Virginia., Przywara K; Asthma and Allergy Foundation of America, Arlington, Virginia., Rank MA; Department of Internal Medicine, Mayo Clinic, Phoenix, Arizona., Bacharier LB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee., Mosnaim G; Department of Medicine, Endeavor Health, Evanston, Illinois., Chu DK; Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address: chudk@mcmaster.ca.
Source: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2025 Sep; Vol. 135 (3), pp. 278-286.e11. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American College of Allergy, Asthma, and Immunology Country of Publication: United States NLM ID: 9503580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4436 (Electronic) Linking ISSN: 10811206 NLM ISO Abbreviation: Ann Allergy Asthma Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Triple therapy vs dual inhaler therapy for moderate-to-severe asthma: An updated systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Rayner+DG%22">Rayner DG</searchLink>; Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bakaa+L%22">Bakaa L</searchLink>; Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada; Harvard TH Chan School of Public Health, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hoyte+F%22">Hoyte F</searchLink>; Department of Medicine, National Jewish Health, Denver, Colorado.<br /><searchLink fieldCode="AU" term="%22Perry+TT%22">Perry TT</searchLink>; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.<br /><searchLink fieldCode="AU" term="%22Rivera-Spoljaric+K%22">Rivera-Spoljaric K</searchLink>; Division of Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Sumino+K%22">Sumino K</searchLink>; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Chipps+B%22">Chipps B</searchLink>; Capital Allergy and Respiratory Disease Center, Sacramento, California.<br /><searchLink fieldCode="AU" term="%22Oppenheimer+J%22">Oppenheimer J</searchLink>; Department of Internal Medicine, University of Medicine and Dentistry of New Jersey/Rutgers New Jersey Medical School, Newark, New Jersey.<br /><searchLink fieldCode="AU" term="%22Nyenhuis+SM%22">Nyenhuis SM</searchLink>; Department of Pediatrics, The University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Israel+E%22">Israel E</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22McCabe+E%22">McCabe E</searchLink>; Hunter-Bellevue School of Nursing, Hunter College, New York, New York.<br /><searchLink fieldCode="AU" term="%22O'Byrne+PM%22">O'Byrne PM</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Shade+LE%22">Shade LE</searchLink>; Department of Family and Community Medicine Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Press+VG%22">Press VG</searchLink>; Department of Medicine, The University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Guyatt+GH%22">Guyatt GH</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rangel+S%22">Rangel S</searchLink>; Los Angeles General Medical Center, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Sue-Wah-Sing+D%22">Sue-Wah-Sing D</searchLink>; Patient and Caregiver Partner.<br /><searchLink fieldCode="AU" term="%22Hall+L%22">Hall L</searchLink>; Patient and Caregiver Partner.<br /><searchLink fieldCode="AU" term="%22Orr+H%22">Orr H</searchLink>; Patient and Caregiver Partner.<br /><searchLink fieldCode="AU" term="%22Melendez+A%22">Melendez A</searchLink>; Patient and Caregiver Partner.<br /><searchLink fieldCode="AU" term="%22Winders+T%22">Winders T</searchLink>; Global Allergy and Airways Patient Platform, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gardner+DD%22">Gardner DD</searchLink>; Allergy and Asthma Network, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Przywara+K%22">Przywara K</searchLink>; Asthma and Allergy Foundation of America, Arlington, Virginia.<br /><searchLink fieldCode="AU" term="%22Rank+MA%22">Rank MA</searchLink>; Department of Internal Medicine, Mayo Clinic, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Bacharier+LB%22">Bacharier LB</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Mosnaim+G%22">Mosnaim G</searchLink>; Department of Medicine, Endeavor Health, Evanston, Illinois.<br /><searchLink fieldCode="AU" term="%22Chu+DK%22">Chu DK</searchLink>; Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address: chudk@mcmaster.ca.
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