View in EDS

Leveraging deep learning and structure-based drug repurposing for the discovery of potent Trk-A inhibitors targeting CIPA.

Saved in:
Bibliographic Details
Title: Leveraging deep learning and structure-based drug repurposing for the discovery of potent Trk-A inhibitors targeting CIPA.
Authors: Iqbal MW; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China., Haider SZ; International Joint Laboratory on Synthetic Biology and Biomass Biorefinery, Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China., Sun X; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China., Al-Ghanim KA; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Nawaz MZ; International Joint Laboratory on Synthetic Biology and Biomass Biorefinery, Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: chzohaib@gmail.com., Yuan Q; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: yuanqp@mail.buct.edu.cn.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Aug; Vol. 163, pp. 108680. Date of Electronic Publication: 2025 Jun 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40517591
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Leveraging deep learning and structure-based drug repurposing for the discovery of potent Trk-A inhibitors targeting CIPA.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Iqbal+MW%22">Iqbal MW</searchLink>; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.<br /><searchLink fieldCode="AU" term="%22Haider+SZ%22">Haider SZ</searchLink>; International Joint Laboratory on Synthetic Biology and Biomass Biorefinery, Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.<br /><searchLink fieldCode="AU" term="%22Al-Ghanim+KA%22">Al-Ghanim KA</searchLink>; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Nawaz+MZ%22">Nawaz MZ</searchLink>; International Joint Laboratory on Synthetic Biology and Biomass Biorefinery, Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: chzohaib@gmail.com.<br /><searchLink fieldCode="AU" term="%22Yuan+Q%22">Yuan Q</searchLink>; State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: yuanqp@mail.buct.edu.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Aug; Vol. 163, pp. 108680. <i>Date of Electronic Publication: </i>2025 Jun 11.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40517591
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.bioorg.2025.108680
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 108680
    Titles:
      – TitleFull: Leveraging deep learning and structure-based drug repurposing for the discovery of potent Trk-A inhibitors targeting CIPA.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Iqbal MW
      – PersonEntity:
          Name:
            NameFull: Haider SZ
      – PersonEntity:
          Name:
            NameFull: Sun X
      – PersonEntity:
          Name:
            NameFull: Al-Ghanim KA
      – PersonEntity:
          Name:
            NameFull: Nawaz MZ
      – PersonEntity:
          Name:
            NameFull: Yuan Q
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: 2025 Aug
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1090-2120
          Numbering:
            – Type: volume
              Value: 163
          Titles:
            – TitleFull: Bioorganic chemistry
              Type: main
ResultId 1