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Doxycycline Enhances Anticancer Activity of Zoledronic Acid via Inducing ROS and Autophagy in Osteosarcoma Cell Lines.

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Title: Doxycycline Enhances Anticancer Activity of Zoledronic Acid via Inducing ROS and Autophagy in Osteosarcoma Cell Lines.
Authors: Li YA; Institute of Translational Medicine and New Drug Development, School of Medicine, China Medical University, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Orthopaedic Department, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan., Chen HY; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan., Hsu CS; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan., Tseng SC; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Hwang E; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Hsieh CP; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan.; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.; Department of Kinesiology, Health and Leisure Studies, Chienkuo Technology University, Changhua, Taiwan., Hung SC; Drug Development Center, Institute of Translational Medicine and New Drug Development, School of Medicine, China Medical University, Taichung, Taiwan.; Integrative Stem Cell Center, China Medical University Hospital, Taichung, Taiwan.; Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan., Huang YF; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2025 May 09; Vol. 22 (11), pp. 2560-2569. Date of Electronic Publication: 2025 May 09 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: Doxycycline Enhances Anticancer Activity of Zoledronic Acid via Inducing ROS and Autophagy in Osteosarcoma Cell Lines.
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  Data: <searchLink fieldCode="AU" term="%22Li+YA%22">Li YA</searchLink>; Institute of Translational Medicine and New Drug Development, School of Medicine, China Medical University, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Orthopaedic Department, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+HY%22">Chen HY</searchLink>; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CS%22">Hsu CS</searchLink>; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+SC%22">Tseng SC</searchLink>; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hwang+E%22">Hwang E</searchLink>; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+CP%22">Hsieh CP</searchLink>; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan.; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.; Department of Kinesiology, Health and Leisure Studies, Chienkuo Technology University, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+SC%22">Hung SC</searchLink>; Drug Development Center, Institute of Translational Medicine and New Drug Development, School of Medicine, China Medical University, Taichung, Taiwan.; Integrative Stem Cell Center, China Medical University Hospital, Taichung, Taiwan.; Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YF%22">Huang YF</searchLink>; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101213954%22">International journal of medical sciences</searchLink> [Int J Med Sci] 2025 May 09; Vol. 22 (11), pp. 2560-2569. <i>Date of Electronic Publication: </i>2025 May 09 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International+Publisher%22">Ivyspring International Publisher </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101213954 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1449-1907 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214491907%22">14491907 </searchLink><i>NLM ISO Abbreviation: </i>Int J Med Sci <i>Subsets: </i>MEDLINE
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              Text: 2025 May 09
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