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The combination of PF-429242 and chloroquine triggers pH-dependent cell death in hepatocellular carcinoma cells.

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Title: The combination of PF-429242 and chloroquine triggers pH-dependent cell death in hepatocellular carcinoma cells.
Authors: Lin JC; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan.; MacKay Junior College of Medicine, Nursing, and Management, New Taipei City 11260, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan., Huang TS; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan., Chen YB; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan., Wu PS; Department of Pathology, MacKay Memorial Hospital, Taipei 10449, Taiwan., Liu TP; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan.; MacKay Junior College of Medicine, Nursing, and Management, New Taipei City 11260, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan., Yang PM; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.; TMU and Affiliated Hospitals Pancreatic Cancer Groups, Taipei Medical University, Taipei 11031, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2025 May 10; Vol. 22 (11), pp. 2583-2593. Date of Electronic Publication: 2025 May 10 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: The combination of PF-429242 and chloroquine triggers pH-dependent cell death in hepatocellular carcinoma cells.
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  Data: <searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan.; MacKay Junior College of Medicine, Nursing, and Management, New Taipei City 11260, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+TS%22">Huang TS</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YB%22">Chen YB</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+PS%22">Wu PS</searchLink>; Department of Pathology, MacKay Memorial Hospital, Taipei 10449, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+TP%22">Liu TP</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei 10449, Taiwan.; MacKay Junior College of Medicine, Nursing, and Management, New Taipei City 11260, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+PM%22">Yang PM</searchLink>; Liver Medical Center, MacKay Memorial Hospital, Taipei 10449, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.; TMU and Affiliated Hospitals Pancreatic Cancer Groups, Taipei Medical University, Taipei 11031, Taiwan.
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