Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD).
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| Title: | Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD). |
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| Authors: | Ng RA; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Barratt S; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Parisian A; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Palanisamy GS; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Phukan S; Aragen Life Sciences Private Ltd., Hyderabad 500076, India., Sun R; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Robello B; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Peña G; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Sapugay J; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Yeghikyan D; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Wang C; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Satish Kher S; Aragen Life Sciences Private Ltd., Hyderabad 500076, India., Thangathirupathy S; Aragen Life Sciences Private Ltd., Hyderabad 500076, India., Millikin R; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Yu G; Synterys, Inc., Union City 94587, California, United States., Watanabe T; Adesis, Inc., New Castle 19720, Delaware, United States., Zhou F; Adesis, Inc., New Castle 19720, Delaware, United States., Rich B; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Duncan A; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Andersen SE; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Chawla R; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Zak DR; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood 60153, Illinois, United States., Heerding DA; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Hearn BR; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Greene G; The Ben May Department for Cancer Research, University of Chicago, Chicago 60637, Illinois, United States., Harmon CL; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Hodges-Gallagher L; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Kushner PJ; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States., Fanning SW; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood 60153, Illinois, United States., Myles DC; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States. |
| Source: | ACS omega [ACS Omega] 2025 May 29; Vol. 10 (22), pp. 22685-22700. Date of Electronic Publication: 2025 May 29 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40521471 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ng+RA%22">Ng RA</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Barratt+S%22">Barratt S</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Parisian+A%22">Parisian A</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Palanisamy+GS%22">Palanisamy GS</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Phukan+S%22">Phukan S</searchLink>; Aragen Life Sciences Private Ltd., Hyderabad 500076, India.<br /><searchLink fieldCode="AU" term="%22Sun+R%22">Sun R</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Robello+B%22">Robello B</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Peña+G%22">Peña G</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Sapugay+J%22">Sapugay J</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Yeghikyan+D%22">Yeghikyan D</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Satish+Kher+S%22">Satish Kher S</searchLink>; Aragen Life Sciences Private Ltd., Hyderabad 500076, India.<br /><searchLink fieldCode="AU" term="%22Thangathirupathy+S%22">Thangathirupathy S</searchLink>; Aragen Life Sciences Private Ltd., Hyderabad 500076, India.<br /><searchLink fieldCode="AU" term="%22Millikin+R%22">Millikin R</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Yu+G%22">Yu G</searchLink>; Synterys, Inc., Union City 94587, California, United States.<br /><searchLink fieldCode="AU" term="%22Watanabe+T%22">Watanabe T</searchLink>; Adesis, Inc., New Castle 19720, Delaware, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+F%22">Zhou F</searchLink>; Adesis, Inc., New Castle 19720, Delaware, United States.<br /><searchLink fieldCode="AU" term="%22Rich+B%22">Rich B</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Duncan+A%22">Duncan A</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Andersen+SE%22">Andersen SE</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Chawla+R%22">Chawla R</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Zak+DR%22">Zak DR</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood 60153, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Heerding+DA%22">Heerding DA</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Hearn+BR%22">Hearn BR</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Greene+G%22">Greene G</searchLink>; The Ben May Department for Cancer Research, University of Chicago, Chicago 60637, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Harmon+CL%22">Harmon CL</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Hodges-Gallagher+L%22">Hodges-Gallagher L</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Kushner+PJ%22">Kushner PJ</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States.<br /><searchLink fieldCode="AU" term="%22Fanning+SW%22">Fanning SW</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood 60153, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Myles+DC%22">Myles DC</searchLink>; Olema Oncology, 780 Brannan Street, San Francisco 94107, California, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101691658%22">ACS omega</searchLink> [ACS Omega] 2025 May 29; Vol. 10 (22), pp. 22685-22700. <i>Date of Electronic Publication: </i>2025 May 29 (<i>Print Publication: </i>2025). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101691658 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2470-1343 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224701343%22">24701343 </searchLink><i>NLM ISO Abbreviation: </i>ACS Omega <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40521471 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acsomega.4c11023 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 22685 Titles: – TitleFull: Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ng RA – PersonEntity: Name: NameFull: Barratt S – PersonEntity: Name: NameFull: Parisian A – PersonEntity: Name: NameFull: Palanisamy GS – PersonEntity: Name: NameFull: Phukan S – PersonEntity: Name: NameFull: Sun R – PersonEntity: Name: NameFull: Robello B – PersonEntity: Name: NameFull: Peña G – PersonEntity: Name: NameFull: Sapugay J – PersonEntity: Name: NameFull: Yeghikyan D – PersonEntity: Name: NameFull: Wang C – PersonEntity: Name: NameFull: Satish Kher S – PersonEntity: Name: NameFull: Thangathirupathy S – PersonEntity: Name: NameFull: Millikin R – PersonEntity: Name: NameFull: Yu G – PersonEntity: Name: NameFull: Watanabe T – PersonEntity: Name: NameFull: Zhou F – PersonEntity: Name: NameFull: Rich B – PersonEntity: Name: NameFull: Duncan A – PersonEntity: Name: NameFull: Andersen SE – PersonEntity: Name: NameFull: Chawla R – PersonEntity: Name: NameFull: Zak DR – PersonEntity: Name: NameFull: Heerding DA – PersonEntity: Name: NameFull: Hearn BR – PersonEntity: Name: NameFull: Greene G – PersonEntity: Name: NameFull: Harmon CL – PersonEntity: Name: NameFull: Hodges-Gallagher L – PersonEntity: Name: NameFull: Kushner PJ – PersonEntity: Name: NameFull: Fanning SW – PersonEntity: Name: NameFull: Myles DC IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 05 Text: 2025 May 29 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2470-1343 Numbering: – Type: volume Value: 10 – Type: issue Value: 22 Titles: – TitleFull: ACS omega Type: main |
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