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Hypoxanthine activates PI3K/AKT pathway and lipid metabolism, hallmarks in breast cancer metastasis.

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Title: Hypoxanthine activates PI3K/AKT pathway and lipid metabolism, hallmarks in breast cancer metastasis.
Authors: Shakartalla SB; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Faculty of Pharmacy, University of Gezira, P.O. Box. 21111, Wadmedani, Sudan., Bouzid A; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates., Altaie AM; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Center of Excellence for Precision Medicine, Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates., Ashmawy NS; Department of Pharmaceutical Sciences, College of Pharmacy, Dubai Medical University, Dubai, United Arab Emirates.; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566, Cairo, Egypt., Al Shareef ZM; College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates., Husseiny MI; Department of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, 91010, USA., Soliman SSM; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. ssoliman@sharjah.ac.ae.; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. ssoliman@sharjah.ac.ae.
Source: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Jun 16; Vol. 42 (7), pp. 263. Date of Electronic Publication: 2025 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hypoxanthine activates PI3K/AKT pathway and lipid metabolism, hallmarks in breast cancer metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Shakartalla+SB%22">Shakartalla SB</searchLink>; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Faculty of Pharmacy, University of Gezira, P.O. Box. 21111, Wadmedani, Sudan.<br /><searchLink fieldCode="AU" term="%22Bouzid+A%22">Bouzid A</searchLink>; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Altaie+AM%22">Altaie AM</searchLink>; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Center of Excellence for Precision Medicine, Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Ashmawy+NS%22">Ashmawy NS</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Dubai Medical University, Dubai, United Arab Emirates.; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Al+Shareef+ZM%22">Al Shareef ZM</searchLink>; College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Husseiny+MI%22">Husseiny MI</searchLink>; Department of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, 91010, USA.<br /><searchLink fieldCode="AU" term="%22Soliman+SSM%22">Soliman SSM</searchLink>; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. ssoliman@sharjah.ac.ae.; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. ssoliman@sharjah.ac.ae.
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  Data: <searchLink fieldCode="JN" term="%229435512%22">Medical oncology (Northwood, London, England)</searchLink> [Med Oncol] 2025 Jun 16; Vol. 42 (7), pp. 263. <i>Date of Electronic Publication: </i>2025 Jun 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9435512 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-131X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213570560%22">13570560 </searchLink><i>NLM ISO Abbreviation: </i>Med Oncol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s12032-025-02829-8
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              Text: 2025 Jun 16
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