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Exploratory digital outcome measures of motor sign progression in Parkinson's disease patients treated with prasinezumab.

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Title: Exploratory digital outcome measures of motor sign progression in Parkinson's disease patients treated with prasinezumab.
Authors: Taylor KI; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. kirsten.taylor@roche.com., Lipsmeier F; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Roche Information Solutions (RIS) Data & Analytics, Roche Diagnostics, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Scelsi MA; Product Development Data Sciences, Roche Products Ltd, Welwyn Garden City, UK.; Chiesi Group, Manchester, United Kingdom., Volkova-Volkmar E; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Rukina D; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Popp W; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Lambrecht S; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Anzures-Cabrera J; Product Development Data Sciences, Roche Products Ltd, Welwyn Garden City, UK., Summers D; Product Development Data Sciences, Roche Products Ltd, Welwyn Garden City, UK., Abt M; Product Development Data Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland., Monnet A; Product Development Data Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland., Kilchenmann T; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Schjodt-Eriksen J; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Roche Information Solutions (RIS) Data & Analytics, Roche Diagnostics, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Essioux L; Product Development Data Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland.; Computer Science Resource and Research Center, Institut Pasteur, Paris, France., Kustermann T; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Zago W; Prothena Biosciences Inc, South San Francisco, California, USA., Svoboda H; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Roche Innovation Center Basel, and Product Development Neuroscience, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Nikolcheva T; Roche Innovation Center Basel, and Product Development Neuroscience, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Postuma RB; Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada., Pagano G; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; University of Exeter Medical School, London, United Kingdom., Lindemann M; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Roche Information Solutions (RIS) Data & Analytics, Roche Diagnostics, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Corporate Authors: PASADENA Investigators, Prasinezumab Study Group
Source: NPJ digital medicine [NPJ Digit Med] 2025 Jun 16; Vol. 8 (1), pp. 365. Date of Electronic Publication: 2025 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101731738 Publication Model: Electronic Cited Medium: Internet ISSN: 2398-6352 (Electronic) Linking ISSN: 23986352 NLM ISO Abbreviation: NPJ Digit Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Exploratory digital outcome measures of motor sign progression in Parkinson's disease patients treated with prasinezumab.
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  Data: <searchLink fieldCode="AU" term="%22Taylor+KI%22">Taylor KI</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. kirsten.taylor@roche.com.<br /><searchLink fieldCode="AU" term="%22Lipsmeier+F%22">Lipsmeier F</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Roche Information Solutions (RIS) Data & Analytics, Roche Diagnostics, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Scelsi+MA%22">Scelsi MA</searchLink>; Product Development Data Sciences, Roche Products Ltd, Welwyn Garden City, UK.; Chiesi Group, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Volkova-Volkmar+E%22">Volkova-Volkmar E</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rukina+D%22">Rukina D</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Popp+W%22">Popp W</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lambrecht+S%22">Lambrecht S</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. 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Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schjodt-Eriksen+J%22">Schjodt-Eriksen J</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Roche Information Solutions (RIS) Data & Analytics, Roche Diagnostics, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Essioux+L%22">Essioux L</searchLink>; Product Development Data Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland.; Computer Science Resource and Research Center, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kustermann+T%22">Kustermann T</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zago+W%22">Zago W</searchLink>; Prothena Biosciences Inc, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Svoboda+H%22">Svoboda H</searchLink>; Roche Pharma Research and Early Development (pRED) Neuroscience & Rare Diseases, Data & Analytics, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Roche Innovation Center Basel, and Product Development Neuroscience, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nikolcheva+T%22">Nikolcheva T</searchLink>; Roche Innovation Center Basel, and Product Development Neuroscience, F. 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