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Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model.

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Title: Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model.
Authors: Schumacher J; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Environmental Biotechnology Group, Department of Geosciences, University of Tübingen, Tübingen, Germany., Müller P; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Interfaculty Institute for Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany.; M3-Research Center for Malignome, Metabolome and Microbiome, University of Tübingen, Tübingen, Germany., Sulzer J; Helmholtz Centre for Infection Research, Helmholtz Institute for RNA-based Infection Research (HIRI) Würzburg, Würzburg, Germany.; Institute for Hygiene and Microbiology, Julius-Maximilians-University of Würzburg, Würzburg, Germany., Faber F; Helmholtz Centre for Infection Research, Helmholtz Institute for RNA-based Infection Research (HIRI) Würzburg, Würzburg, Germany.; Institute for Hygiene and Microbiology, Julius-Maximilians-University of Würzburg, Würzburg, Germany., Molitor B; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Environmental Biotechnology Group, Department of Geosciences, University of Tübingen, Tübingen, Germany., Maier L; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Interfaculty Institute for Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany.; M3-Research Center for Malignome, Metabolome and Microbiome, University of Tübingen, Tübingen, Germany.
Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2519697. Date of Electronic Publication: 2025 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model.
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  Data: <searchLink fieldCode="AU" term="%22Schumacher+J%22">Schumacher J</searchLink>; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Environmental Biotechnology Group, Department of Geosciences, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+P%22">Müller P</searchLink>; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Interfaculty Institute for Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany.; M3-Research Center for Malignome, Metabolome and Microbiome, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Sulzer+J%22">Sulzer J</searchLink>; Helmholtz Centre for Infection Research, Helmholtz Institute for RNA-based Infection Research (HIRI) Würzburg, Würzburg, Germany.; Institute for Hygiene and Microbiology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Faber+F%22">Faber F</searchLink>; Helmholtz Centre for Infection Research, Helmholtz Institute for RNA-based Infection Research (HIRI) Würzburg, Würzburg, Germany.; Institute for Hygiene and Microbiology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Molitor+B%22">Molitor B</searchLink>; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Environmental Biotechnology Group, Department of Geosciences, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Maier+L%22">Maier L</searchLink>; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.; Interfaculty Institute for Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany.; M3-Research Center for Malignome, Metabolome and Microbiome, University of Tübingen, Tübingen, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101495343%22">Gut microbes</searchLink> [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2519697. <i>Date of Electronic Publication: </i>2025 Jun 16.
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