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Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation.

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Title: Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation.
Authors: Chen J; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. jiajinchen@xmu.edu.cn., Li S; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China., Bu S; Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China., Nie X; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China., Zhang L; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China., Jie L; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China., Fang Y; National Institute for Data Science in Health and Medicine, Center for Aging and Health Research, School of Public Health, Xiamen University, No. 4221, Xiang'an South Road, Xiamen, 361102, Fujian, China. fangya@xmu.edu.cn., Dai C; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. cuiliand2013@126.com.; Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. cuiliand2013@126.com., Wang Y; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. wy@medmail.com.cn.; Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. wy@medmail.com.cn.
Source: GeroScience [Geroscience] 2026 Feb; Vol. 48 (1), pp. 1323-1336. Date of Electronic Publication: 2025 Jun 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. jiajinchen@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Bu+S%22">Bu S</searchLink>; Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Nie+X%22">Nie X</searchLink>; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Jie+L%22">Jie L</searchLink>; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Fang+Y%22">Fang Y</searchLink>; National Institute for Data Science in Health and Medicine, Center for Aging and Health Research, School of Public Health, Xiamen University, No. 4221, Xiang'an South Road, Xiamen, 361102, Fujian, China. fangya@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Dai+C%22">Dai C</searchLink>; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. cuiliand2013@126.com.; Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. cuiliand2013@126.com.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. wy@medmail.com.cn.; Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2999 Jinshan Road, Xiamen, 361006, Fujian, China. wy@medmail.com.cn.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Feb; Vol. 48 (1), pp. 1323-1336. <i>Date of Electronic Publication: </i>2025 Jun 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11357-025-01734-2
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              Text: 2026 Feb
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              Y: 2026
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