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Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation.

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Title: Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation.
Authors: Green SA; Genentech Inc., South San Francisco, California 94080, United States., Smith RT; Genentech Inc., South San Francisco, California 94080, United States., Grandner JM; Genentech Inc., South San Francisco, California 94080, United States., Zeng M; Genentech Inc., South San Francisco, California 94080, United States., Del Bel M; Genentech Inc., South San Francisco, California 94080, United States., Zhu BY; Genentech Inc., South San Francisco, California 94080, United States., Liang J; Genentech Inc., South San Francisco, California 94080, United States., Braun MG; Genentech Inc., South San Francisco, California 94080, United States., Sudhamsu J; Genentech Inc., South San Francisco, California 94080, United States., Wallweber HA; Genentech Inc., South San Francisco, California 94080, United States., Boenig G; Genentech Inc., South San Francisco, California 94080, United States., Murray J; Genentech Inc., South San Francisco, California 94080, United States., Shen X; WuXi AppTec Co., Ltd., WaiGaoQiao Free Trade Zone, Shanghai, 200131, P. R. China., Zhang R; WuXi AppTec Co., Ltd., WaiGaoQiao Free Trade Zone, Shanghai, 200131, P. R. China., Lai KW; WuXi AppTec Co., Ltd., WaiGaoQiao Free Trade Zone, Shanghai, 200131, P. R. China., Delwig A; Genentech Inc., South San Francisco, California 94080, United States., Breboneria MA; Genentech Inc., South San Francisco, California 94080, United States., Ly J; Genentech Inc., South San Francisco, California 94080, United States., Ganti A; Genentech Inc., South San Francisco, California 94080, United States., Nespi M; Genentech Inc., South San Francisco, California 94080, United States., Weber M; Genentech Inc., South San Francisco, California 94080, United States., Leahey R; Genentech Inc., South San Francisco, California 94080, United States., Hinz FI; Genentech Inc., South San Francisco, California 94080, United States., Chan BK; Genentech Inc., South San Francisco, California 94080, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2025 May 20; Vol. 16 (6), pp. 1147-1154. Date of Electronic Publication: 2025 May 20 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2025 May 20; Vol. 16 (6), pp. 1147-1154. <i>Date of Electronic Publication: </i>2025 May 20 (<i>Print Publication: </i>2025).
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        Value: 10.1021/acsmedchemlett.5c00189
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