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Discovery of a functionally selective serotonin receptor (5-HT1AR) agonist for the treatment of pain.

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Title: Discovery of a functionally selective serotonin receptor (5-HT1AR) agonist for the treatment of pain.
Authors: Ullrich A; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Schneider J; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Braz JM; Department of Anatomy, University of California, San Francisco, CA, USA., Neu E; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Staffen N; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Stanek M; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Bláhová J; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Hove T; Rudolf-Virchow-Center, Julius-Maximilians-Universität, Würzburg, Germany., Albert T; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Allikalt A; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Löber S; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Bhardwaj K; Department of Anatomy, University of California, San Francisco, CA, USA., Rodriguez-Rosado S; Department of Anatomy, University of California, San Francisco, CA, USA., Fink E; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Graduate Program in Biophysics, University of California, San Francisco, CA, USA., Rasmussen T; Rudolf-Virchow-Center, Julius-Maximilians-Universität, Würzburg, Germany., Hübner H; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Shoichet BK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA., Basbaum AI; Department of Anatomy, University of California, San Francisco, CA, USA., Böttcher B; Rudolf-Virchow-Center, Julius-Maximilians-Universität, Würzburg, Germany., Weikert D; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany., Gmeiner P; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAU NeW, Erlangen, Germany.
Source: Science advances [Sci Adv] 2025 Jun 20; Vol. 11 (25), pp. eadv9267. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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