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Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.

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Title: Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.
Authors: Schönfeld J; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Brunst S; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt am Main, Germany., Ciomirtan L; Institute of Pharmaceutical Biology, Goethe University, 60438 Frankfurt am Main, Germany., Willmer L; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Member of Fraunhofer Cluster Immune Mediated Diseases (CIMD), 60596 Frankfurt am Main, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany., Chromik MA; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, 42119 Wuppertal, Germany., Kumar A; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Froemel T; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, 60596 Frankfurt am Main, Germany., Liebisch N; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Hackspacher A; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Ehrler JHM; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Wintermeier L; Institute of Pharmaceutical Biology, Goethe University, 60438 Frankfurt am Main, Germany., Hesse C; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Member of Fraunhofer Cluster Immune Mediated Diseases (CIMD), 60596 Frankfurt am Main, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany., Fiedler J; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Member of Fraunhofer Cluster Immune Mediated Diseases (CIMD), 60596 Frankfurt am Main, Germany., Heering J; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt am Main, Germany., Freitag H; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany.; Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany., Zardo P; Department of Cardiothoracic Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany., Fieguth HG; KRH Clinics Hannover, 30459 Hannover, Germany., Brüggerhoff A; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Jakob J; Department of Medicine, Hematology and Oncology, University Hospital, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), 60596 Frankfurt am Main, Germany., Häupl B; Department of Medicine, Hematology and Oncology, University Hospital, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), 60596 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, 60590 Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Weizel L; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Kaiser A; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Schubert-Zsilavecz M; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany., Oellerich T; Department of Medicine, Hematology and Oncology, University Hospital, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), 60596 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, 60590 Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; University Cancer Center (UCT), 60590 Frankfurt am Main, Germany., Fleming I; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, 60596 Frankfurt am Main, Germany., Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, 42119 Wuppertal, Germany., Fürst R; Pharmaceutical Biology, Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Kannt A; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt am Main, Germany.; Institute for Clinical Pharmacology, Goethe University, 60596 Frankfurt am Main, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, 60438 Frankfurt am Main, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt am Main, Germany., Hiesinger K; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Jul 10; Vol. 68 (13), pp. 13728-13749. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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Frankfurt Cancer Institute (FCI), 60596 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, 60590 Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; University Cancer Center (UCT), 60590 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Fleming+I%22">Fleming I</searchLink>; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, 60596 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Schebb+NH%22">Schebb NH</searchLink>; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, 42119 Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Fürst+R%22">Fürst R</searchLink>; Pharmaceutical Biology, Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kannt+A%22">Kannt A</searchLink>; 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