Pharmacological evaluation of non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury.
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| Title: | Pharmacological evaluation of non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury. |
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| Authors: | Valencia I; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Pastor-Martínez A; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Decouty-Pérez C; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Lopez-Rodriguez AB; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Álvarez-Rubal M; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Ramos E; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain., Calzaferri F; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; School of Chemical Science, Dublin City University (DCU), Dublin, Ireland., Zamorano-Fernández J; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Giner-García J; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Palpán-Flores AJ; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Rodríguez-Domínguez V; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Rodríguez de Cía J; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain., Hernández-García BJ; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Romero A; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain., de Los Ríos C; Department of Basic Health Sciences, School of Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Spain.; High Performance Research Group in Physiopathology and Pharmacology of the Digestive System-Universidad Rey Juan Carlos (NeuGut-URJC), Alcorcón, Spain., Egea J; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain. |
| Source: | British journal of pharmacology [Br J Pharmacol] 2025 Oct; Vol. 182 (19), pp. 4693-4709. Date of Electronic Publication: 2025 Jun 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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