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Targeting Neutrophil-Mediated Inflammation: Identification of Pyrazolidinone Carboxamide Derivatives as Potent Selective Inhibitors of Formyl Peptide Receptor 1 (FPR1)-Activated Neutrophils.

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Title: Targeting Neutrophil-Mediated Inflammation: Identification of Pyrazolidinone Carboxamide Derivatives as Potent Selective Inhibitors of Formyl Peptide Receptor 1 (FPR1)-Activated Neutrophils.
Authors: Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Wagdy RA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Salah M; Department of Pharmaceutical Chemistry, School of Pharmacy, Newgiza University (NGU), Newgiza 12577, Cairo, Egypt., Wang YH; Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., Cheng TP; Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., Lee YR; Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan., Chen YC; Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.; Center for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan., Mandour YM; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo 11578, Egypt., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken 66123, Germany., Hwang TL; Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 235056, Taiwan.
Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2025 May 02; Vol. 8 (6), pp. 1591-1609. Date of Electronic Publication: 2025 May 02 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Abdel-Halim+M%22">Abdel-Halim M</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Wagdy+RA%22">Wagdy RA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Salah+M%22">Salah M</searchLink>; Department of Pharmaceutical Chemistry, School of Pharmacy, Newgiza University (NGU), Newgiza 12577, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Wang+YH%22">Wang YH</searchLink>; Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+TP%22">Cheng TP</searchLink>; Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YR%22">Lee YR</searchLink>; Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.; Center for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.<br /><searchLink fieldCode="AU" term="%22Mandour+YM%22">Mandour YM</searchLink>; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo 11578, Egypt.<br /><searchLink fieldCode="AU" term="%22Abadi+AH%22">Abadi AH</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Engel+M%22">Engel M</searchLink>; Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken 66123, Germany.<br /><searchLink fieldCode="AU" term="%22Hwang+TL%22">Hwang TL</searchLink>; Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Graduate Institute of Health Industry Technology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 235056, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101721411%22">ACS pharmacology & translational science</searchLink> [ACS Pharmacol Transl Sci] 2025 May 02; Vol. 8 (6), pp. 1591-1609. <i>Date of Electronic Publication: </i>2025 May 02 (<i>Print Publication: </i>2025).
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