View in EDS

Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1.

Saved in:
Bibliographic Details
Title: Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1.
Authors: Soday L; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Seripracharat C; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Gray JL; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Luz AFS; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal., Howard RT; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Singh R; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Burden TJ; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Bernardini E; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Mateus-Pinheiro M; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal., Petersen J; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Gunnarsson A; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Gunnarsson J; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Aagaard A; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Sjögren T; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Maslen S; The Francis Crick Institute, London NW1 1AT, U.K., Bartlett EJ; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Iles AF; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K., Smith DM; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K., Scott JS; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K., Skehel M; The Francis Crick Institute, London NW1 1AT, U.K., Davis AM; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K., Ressurreição AS; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal., Moreira R; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal., Rodrigues CMP; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal., Shenoy AR; Department of Infectious Diseases, Imperial College London, Flowers Building, South Kensington Campus, London SW7 2AZ, U.K., Tate EW; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.; The Francis Crick Institute, London NW1 1AT, U.K.
Source: ACS chemical biology [ACS Chem Biol] 2025 Jul 18; Vol. 20 (7), pp. 1527-1543. Date of Electronic Publication: 2025 Jun 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40539767
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Soday+L%22">Soday L</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Seripracharat+C%22">Seripracharat C</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Gray+JL%22">Gray JL</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Luz+AFS%22">Luz AFS</searchLink>; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal.<br /><searchLink fieldCode="AU" term="%22Howard+RT%22">Howard RT</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Singh+R%22">Singh R</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Burden+TJ%22">Burden TJ</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Bernardini+E%22">Bernardini E</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Mateus-Pinheiro+M%22">Mateus-Pinheiro M</searchLink>; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal.<br /><searchLink fieldCode="AU" term="%22Petersen+J%22">Petersen J</searchLink>; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Gunnarsson+A%22">Gunnarsson A</searchLink>; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Gunnarsson+J%22">Gunnarsson J</searchLink>; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Aagaard+A%22">Aagaard A</searchLink>; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Sjögren+T%22">Sjögren T</searchLink>; Discovery Sciences, R&D Gothenburg, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Maslen+S%22">Maslen S</searchLink>; The Francis Crick Institute, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Bartlett+EJ%22">Bartlett EJ</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Iles+AF%22">Iles AF</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.<br /><searchLink fieldCode="AU" term="%22Smith+DM%22">Smith DM</searchLink>; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Scott+JS%22">Scott JS</searchLink>; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Skehel+M%22">Skehel M</searchLink>; The Francis Crick Institute, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Davis+AM%22">Davis AM</searchLink>; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Ressurreição+AS%22">Ressurreição AS</searchLink>; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal.<br /><searchLink fieldCode="AU" term="%22Moreira+R%22">Moreira R</searchLink>; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal.<br /><searchLink fieldCode="AU" term="%22Rodrigues+CMP%22">Rodrigues CMP</searchLink>; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-004, Portugal.<br /><searchLink fieldCode="AU" term="%22Shenoy+AR%22">Shenoy AR</searchLink>; Department of Infectious Diseases, Imperial College London, Flowers Building, South Kensington Campus, London SW7 2AZ, U.K.<br /><searchLink fieldCode="AU" term="%22Tate+EW%22">Tate EW</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.; The Francis Crick Institute, London NW1 1AT, U.K.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101282906%22">ACS chemical biology</searchLink> [ACS Chem Biol] 2025 Jul 18; Vol. 20 (7), pp. 1527-1543. <i>Date of Electronic Publication: </i>2025 Jun 20.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101282906 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1554-8937 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215548929%22">15548929 </searchLink><i>NLM ISO Abbreviation: </i>ACS Chem Biol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40539767
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acschembio.5c00112
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1527
    Titles:
      – TitleFull: Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Soday L
      – PersonEntity:
          Name:
            NameFull: Seripracharat C
      – PersonEntity:
          Name:
            NameFull: Gray JL
      – PersonEntity:
          Name:
            NameFull: Luz AFS
      – PersonEntity:
          Name:
            NameFull: Howard RT
      – PersonEntity:
          Name:
            NameFull: Singh R
      – PersonEntity:
          Name:
            NameFull: Burden TJ
      – PersonEntity:
          Name:
            NameFull: Bernardini E
      – PersonEntity:
          Name:
            NameFull: Mateus-Pinheiro M
      – PersonEntity:
          Name:
            NameFull: Petersen J
      – PersonEntity:
          Name:
            NameFull: Gunnarsson A
      – PersonEntity:
          Name:
            NameFull: Gunnarsson J
      – PersonEntity:
          Name:
            NameFull: Aagaard A
      – PersonEntity:
          Name:
            NameFull: Sjögren T
      – PersonEntity:
          Name:
            NameFull: Maslen S
      – PersonEntity:
          Name:
            NameFull: Bartlett EJ
      – PersonEntity:
          Name:
            NameFull: Iles AF
      – PersonEntity:
          Name:
            NameFull: Smith DM
      – PersonEntity:
          Name:
            NameFull: Scott JS
      – PersonEntity:
          Name:
            NameFull: Skehel M
      – PersonEntity:
          Name:
            NameFull: Davis AM
      – PersonEntity:
          Name:
            NameFull: Ressurreição AS
      – PersonEntity:
          Name:
            NameFull: Moreira R
      – PersonEntity:
          Name:
            NameFull: Rodrigues CMP
      – PersonEntity:
          Name:
            NameFull: Shenoy AR
      – PersonEntity:
          Name:
            NameFull: Tate EW
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 18
              M: 07
              Text: 2025 Jul 18
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1554-8937
          Numbering:
            – Type: volume
              Value: 20
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: ACS chemical biology
              Type: main
ResultId 1