A first-in-class EGFR-directed KRAS G12V selective inhibitor.

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Bibliographic Details
Title: A first-in-class EGFR-directed KRAS G12V selective inhibitor.
Authors: Stanland LJ; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA., Huggins HP; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Sahoo SS; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Porrello A; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Chareddy Y; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Genetics and Molecular Biology, UNC at Chapel Hill, Chapel Hill, NC, USA., Azam SH; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Perry JL; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Center for Nanotechnology in Drug Delivery, Chapel Hill, NC, USA; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA., Pallan PS; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA., Whately K; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Edatt L; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Green WD; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC at Chapel Hill, Chapel Hill, NC, USA., Fleming MC; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA; Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, NC, USA., Im J; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Gutierrez-Ford C; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Simmons I; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Dawoud A; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Zhou KI; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Medical Oncology, Duke University, Durham, NC 27705, USA., Jayaprakash V; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Sellers RS; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA., Cruz G; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA., Wielgus A; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA., Milner J; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC at Chapel Hill, Chapel Hill, NC, USA., Egli M; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA., Bowers AA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA; Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, NC, USA; Department of Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA., Pecot CV; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Hematology/Oncology, UNC at Chapel Hill, Chapel Hill, NC, USA. Electronic address: pecot@email.unc.edu.
Source: Cancer cell [Cancer Cell] 2025 Oct 13; Vol. 43 (10), pp. 1815-1832.e10. Date of Electronic Publication: 2025 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-3686
DOI:10.1016/j.ccell.2025.05.016