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A first-in-class EGFR-directed KRAS G12V selective inhibitor.

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Title: A first-in-class EGFR-directed KRAS G12V selective inhibitor.
Authors: Stanland LJ; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA., Huggins HP; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Sahoo SS; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Porrello A; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Chareddy Y; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Genetics and Molecular Biology, UNC at Chapel Hill, Chapel Hill, NC, USA., Azam SH; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Perry JL; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Center for Nanotechnology in Drug Delivery, Chapel Hill, NC, USA; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA., Pallan PS; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA., Whately K; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Edatt L; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Green WD; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC at Chapel Hill, Chapel Hill, NC, USA., Fleming MC; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA; Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, NC, USA., Im J; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Gutierrez-Ford C; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Simmons I; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Dawoud A; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA., Zhou KI; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Medical Oncology, Duke University, Durham, NC 27705, USA., Jayaprakash V; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA., Sellers RS; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA., Cruz G; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA., Wielgus A; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA., Milner J; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC at Chapel Hill, Chapel Hill, NC, USA., Egli M; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA., Bowers AA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA; Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, NC, USA; Department of Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA., Pecot CV; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Hematology/Oncology, UNC at Chapel Hill, Chapel Hill, NC, USA. Electronic address: pecot@email.unc.edu.
Source: Cancer cell [Cancer Cell] 2025 Oct 13; Vol. 43 (10), pp. 1815-1832.e10. Date of Electronic Publication: 2025 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A first-in-class EGFR-directed KRAS G12V selective inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Stanland+LJ%22">Stanland LJ</searchLink>; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA.<br /><searchLink fieldCode="AU" term="%22Huggins+HP%22">Huggins HP</searchLink>; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sahoo+SS%22">Sahoo SS</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Porrello+A%22">Porrello A</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chareddy+Y%22">Chareddy Y</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Genetics and Molecular Biology, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Azam+SH%22">Azam SH</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Perry+JL%22">Perry JL</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Center for Nanotechnology in Drug Delivery, Chapel Hill, NC, USA; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pallan+PS%22">Pallan PS</searchLink>; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Whately+K%22">Whately K</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Edatt+L%22">Edatt L</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Green+WD%22">Green WD</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Fleming+MC%22">Fleming MC</searchLink>; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA; Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Im+J%22">Im J</searchLink>; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gutierrez-Ford+C%22">Gutierrez-Ford C</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Simmons+I%22">Simmons I</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Dawoud+A%22">Dawoud A</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+KI%22">Zhou KI</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Medical Oncology, Duke University, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Jayaprakash+V%22">Jayaprakash V</searchLink>; EnFuego Therapeutics, Inc, Morrisville, NC 27560, USA; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sellers+RS%22">Sellers RS</searchLink>; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cruz+G%22">Cruz G</searchLink>; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wielgus+A%22">Wielgus A</searchLink>; Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Milner+J%22">Milner J</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Egli+M%22">Egli M</searchLink>; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Bowers+AA%22">Bowers AA</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Chemical Biology and Medicinal Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA; Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, NC, USA; Department of Chemistry, UNC at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pecot+CV%22">Pecot CV</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; RNA Discovery Center, UNC at Chapel Hill, Chapel Hill, NC, USA; Division of Hematology/Oncology, UNC at Chapel Hill, Chapel Hill, NC, USA. Electronic address: pecot@email.unc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101130617%22">Cancer cell</searchLink> [Cancer Cell] 2025 Oct 13; Vol. 43 (10), pp. 1815-1832.e10. <i>Date of Electronic Publication: </i>2025 Jun 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130617 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-3686 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215356108%22">15356108 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Cell <i>Subsets: </i>MEDLINE
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