Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.

Saved in:
Bibliographic Details
Title: Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.
Authors: Maertens JA; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium; Department of Hematology, University Hospitals Leuven, Leuven, Belgium. Electronic address: johan.maertens@uzleuven.be., Thompson GR 3rd; Division of Infectious Diseases, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA, USA., Spec A; Division of Infectious Disease, Washington University in St Louis School of Medicine, St Louis, MO, USA., Donovan FM; Valley Fever Center for Excellence, Division of Infectious Diseases, Department of Medicine, University of Arizona, Tucson, AZ, USA., Hammond SP; Division of Infectious Diseases and Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bruns AHW; Department of Internal Medicine and Infectious Diseases, University Medical Center, Utrecht, Netherlands., Rahav G; Infectious Diseases Unit, Chaim Sheba Medical Center, Ariel University, Ariel, Israel., Shoham S; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Johnson R; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Division of Infectious Diseases and Valley Fever Institute, Kern Medical, Bakersfield, CA, USA., Rijnders B; Department of Internal Medicine, Section of Infectious Diseases, and Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, Netherlands., Schaenman J; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Hoenigl M; Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Biotechmed-Graz, Graz, Austria., Morrissey CO; Department of Infectious Diseases, Alfred Health, Melbourne, VIC, Australia; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Mehta SR; Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, USA; Infectious Diseases Section, San Diego Veterans Affairs Medical Center, San Diego, CA, USA., Heath CH; Department of Microbiology, PathWest Laboratory Medicine, Fiona Stanley Hospital, Murdoch, WA, Australia; Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, WA, Australia; Department of Medicine, University of Western Australia, Crawley, WA, Australia., Koehler P; European Confederation of Medical Mycology (ECMM) Excellence Center, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Division of Clinical Immunology, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute of Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Paterson DL; ADVANCE-ID, Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Slavin MA; Department of Infectious Diseases and Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital and The National Centre for Infections in Cancer, University of Melbourne, Melbourne, VIC, Australia., Fortún J; Infectious Diseases Department, Hospital Ramón y Cajal, Madrid, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Facultad de Medicina, Universidad de Alcalá, Madrid, Spain., Nguyen MH; University of Pittsburgh, Pittsburgh, PA, USA., Patterson TF; Department of Medicine, Division of Infectious Diseases, University of Texas Health San Antonio, San Antonio, TX, USA., Uspenskaya O; Leningrad Regional Clinical Hospital, St Petersburg, Russia., Van de Veerdonk FL; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, Netherlands., Verweij PE; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands; Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, Netherlands., Aoun M; Infectious Diseases Department, Institut Jules Bordet, Brussels, Belgium., Georgala A; Infectious Diseases Department, Institut Jules Bordet, Brussels, Belgium., Alexander BD; Department of Medicine (Infectious Diseases) and Department of Pathology, Duke University, Durham, NC, USA., Chayakulkeeree M; Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Mehra V; Department of Haematological Medicine, King's College Hospital, London, UK., Miceli MH; Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI, USA., Sikka MK; Department of Medicine, Division of Infectious Diseases, Oregon Health & Science University, Portland, OR, USA., Solé A; Lung Transplant Unit and Adult Cystic Fibrosis Unit, Hospital Universitari i Politecnic La Fe, Valencia, Spain; Department of Medicine, Division of Pneumology, Universitat de Valencia, Valencia, Spain., Walsh TJ; Center for Innovative Therapeutics and Diagnostics, Richmond, VA, USA; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA., Aguado JM; Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain., Holland SM; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA., Moussa M; Hematology and Bone Marrow Transplantation Department, Ain Shams University, Cairo, Egypt., Rautemaa-Richardson R; Mycology Reference Centre Manchester, ECMM Centre of Excellence, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Department of Infectious Diseases, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Bazaz R; Department of Infectious Diseases, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Schwartz S; Department of Haematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, Berlin, Germany., Walsh SR; Division of Infectious Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Plate M; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA., Yehudai-Ofir D; Hematology Institute, Rambam Health Care Campus, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel., Brüggemann RJ; Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands; Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, Netherlands., Cornely OA; European Confederation of Medical Mycology (ECMM) Excellence Center, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Division of Infectious Diseases, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute of Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany., Ostrosky-Zeichner L; University of Texas Health Science Center at Houston, Houston, TX, USA., Vazquez JA; Department of Medicine, Division of Infectious Diseases, Medical College of Georgia, Augusta University, Augusta, GA, USA., White PL; Public Health Wales Mycology Regional Reference Laboratory, University Hospital of Wales, Cardiff, UK; Centre for Trials Research, Division of Infection and Immunity, Cardiff University, Cardiff, UK., Cornelissen K; F2G, Nether Alderley, Macclesfield, UK., Ross GG; F2G, Nether Alderley, Macclesfield, UK., Fitton L; F2G, Nether Alderley, Macclesfield, UK., Dane A; DaneStat Consulting, Macclesfield, UK., Zinzi D; F2G, Nether Alderley, Macclesfield, UK., Rex JH; F2G, Nether Alderley, Macclesfield, UK., Chen SC; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia; Department of Infectious Diseases, Westmead Hospital, Sydney, NSW, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2025 Nov; Vol. 25 (11), pp. 1177-1188. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40541222
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Maertens+JA%22">Maertens JA</searchLink>; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium; Department of Hematology, University Hospitals Leuven, Leuven, Belgium. Electronic address: johan.maertens@uzleuven.be.<br /><searchLink fieldCode="AU" term="%22Thompson+GR+3rd%22">Thompson GR 3rd</searchLink>; Division of Infectious Diseases, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Spec+A%22">Spec A</searchLink>; Division of Infectious Disease, Washington University in St Louis School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Donovan+FM%22">Donovan FM</searchLink>; Valley Fever Center for Excellence, Division of Infectious Diseases, Department of Medicine, University of Arizona, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Hammond+SP%22">Hammond SP</searchLink>; Division of Infectious Diseases and Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bruns+AHW%22">Bruns AHW</searchLink>; Department of Internal Medicine and Infectious Diseases, University Medical Center, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rahav+G%22">Rahav G</searchLink>; Infectious Diseases Unit, Chaim Sheba Medical Center, Ariel University, Ariel, Israel.<br /><searchLink fieldCode="AU" term="%22Shoham+S%22">Shoham S</searchLink>; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+R%22">Johnson R</searchLink>; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Division of Infectious Diseases and Valley Fever Institute, Kern Medical, Bakersfield, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rijnders+B%22">Rijnders B</searchLink>; Department of Internal Medicine, Section of Infectious Diseases, and Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schaenman+J%22">Schaenman J</searchLink>; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hoenigl+M%22">Hoenigl M</searchLink>; Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Biotechmed-Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Morrissey+CO%22">Morrissey CO</searchLink>; Department of Infectious Diseases, Alfred Health, Melbourne, VIC, Australia; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mehta+SR%22">Mehta SR</searchLink>; Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, USA; Infectious Diseases Section, San Diego Veterans Affairs Medical Center, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Heath+CH%22">Heath CH</searchLink>; Department of Microbiology, PathWest Laboratory Medicine, Fiona Stanley Hospital, Murdoch, WA, Australia; Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, WA, Australia; Department of Medicine, University of Western Australia, Crawley, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Koehler+P%22">Koehler P</searchLink>; European Confederation of Medical Mycology (ECMM) Excellence Center, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Division of Clinical Immunology, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute of Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Paterson+DL%22">Paterson DL</searchLink>; ADVANCE-ID, Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Slavin+MA%22">Slavin MA</searchLink>; Department of Infectious Diseases and Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital and The National Centre for Infections in Cancer, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Fortún+J%22">Fortún J</searchLink>; Infectious Diseases Department, Hospital Ramón y Cajal, Madrid, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Facultad de Medicina, Universidad de Alcalá, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Nguyen+MH%22">Nguyen MH</searchLink>; University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Patterson+TF%22">Patterson TF</searchLink>; Department of Medicine, Division of Infectious Diseases, University of Texas Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Uspenskaya+O%22">Uspenskaya O</searchLink>; Leningrad Regional Clinical Hospital, St Petersburg, Russia.<br /><searchLink fieldCode="AU" term="%22Van+de+Veerdonk+FL%22">Van de Veerdonk FL</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Verweij+PE%22">Verweij PE</searchLink>; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands; Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Aoun+M%22">Aoun M</searchLink>; Infectious Diseases Department, Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Georgala+A%22">Georgala A</searchLink>; Infectious Diseases Department, Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Alexander+BD%22">Alexander BD</searchLink>; Department of Medicine (Infectious Diseases) and Department of Pathology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chayakulkeeree+M%22">Chayakulkeeree M</searchLink>; Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Mehra+V%22">Mehra V</searchLink>; Department of Haematological Medicine, King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Miceli+MH%22">Miceli MH</searchLink>; Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sikka+MK%22">Sikka MK</searchLink>; Department of Medicine, Division of Infectious Diseases, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Solé+A%22">Solé A</searchLink>; Lung Transplant Unit and Adult Cystic Fibrosis Unit, Hospital Universitari i Politecnic La Fe, Valencia, Spain; Department of Medicine, Division of Pneumology, Universitat de Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Walsh+TJ%22">Walsh TJ</searchLink>; Center for Innovative Therapeutics and Diagnostics, Richmond, VA, USA; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Aguado+JM%22">Aguado JM</searchLink>; Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Holland+SM%22">Holland SM</searchLink>; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Moussa+M%22">Moussa M</searchLink>; Hematology and Bone Marrow Transplantation Department, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Rautemaa-Richardson+R%22">Rautemaa-Richardson R</searchLink>; Mycology Reference Centre Manchester, ECMM Centre of Excellence, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Department of Infectious Diseases, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Bazaz+R%22">Bazaz R</searchLink>; Department of Infectious Diseases, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Schwartz+S%22">Schwartz S</searchLink>; Department of Haematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Walsh+SR%22">Walsh SR</searchLink>; Division of Infectious Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Plate+M%22">Plate M</searchLink>; Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yehudai-Ofir+D%22">Yehudai-Ofir D</searchLink>; Hematology Institute, Rambam Health Care Campus, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Brüggemann+RJ%22">Brüggemann RJ</searchLink>; Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands; Radboudumc-CWZ Center of Expertise for Mycology, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Cornely+OA%22">Cornely OA</searchLink>; European Confederation of Medical Mycology (ECMM) Excellence Center, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Division of Infectious Diseases, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute of Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ostrosky-Zeichner+L%22">Ostrosky-Zeichner L</searchLink>; University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vazquez+JA%22">Vazquez JA</searchLink>; Department of Medicine, Division of Infectious Diseases, Medical College of Georgia, Augusta University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22White+PL%22">White PL</searchLink>; Public Health Wales Mycology Regional Reference Laboratory, University Hospital of Wales, Cardiff, UK; Centre for Trials Research, Division of Infection and Immunity, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Cornelissen+K%22">Cornelissen K</searchLink>; F2G, Nether Alderley, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Ross+GG%22">Ross GG</searchLink>; F2G, Nether Alderley, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Fitton+L%22">Fitton L</searchLink>; F2G, Nether Alderley, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Dane+A%22">Dane A</searchLink>; DaneStat Consulting, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Zinzi+D%22">Zinzi D</searchLink>; F2G, Nether Alderley, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Rex+JH%22">Rex JH</searchLink>; F2G, Nether Alderley, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Chen+SC%22">Chen SC</searchLink>; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia; Department of Infectious Diseases, Westmead Hospital, Sydney, NSW, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2025 Nov; Vol. 25 (11), pp. 1177-1188. <i>Date of Electronic Publication: </i>2025 Jun 18.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial, Phase II; Multicenter Study
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130150 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-4457 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214733099%22">14733099 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Infect Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40541222
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S1473-3099(25)00224-5
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1177
    Titles:
      – TitleFull: Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Maertens JA
      – PersonEntity:
          Name:
            NameFull: Thompson GR 3rd
      – PersonEntity:
          Name:
            NameFull: Spec A
      – PersonEntity:
          Name:
            NameFull: Donovan FM
      – PersonEntity:
          Name:
            NameFull: Hammond SP
      – PersonEntity:
          Name:
            NameFull: Bruns AHW
      – PersonEntity:
          Name:
            NameFull: Rahav G
      – PersonEntity:
          Name:
            NameFull: Shoham S
      – PersonEntity:
          Name:
            NameFull: Johnson R
      – PersonEntity:
          Name:
            NameFull: Rijnders B
      – PersonEntity:
          Name:
            NameFull: Schaenman J
      – PersonEntity:
          Name:
            NameFull: Hoenigl M
      – PersonEntity:
          Name:
            NameFull: Morrissey CO
      – PersonEntity:
          Name:
            NameFull: Mehta SR
      – PersonEntity:
          Name:
            NameFull: Heath CH
      – PersonEntity:
          Name:
            NameFull: Koehler P
      – PersonEntity:
          Name:
            NameFull: Paterson DL
      – PersonEntity:
          Name:
            NameFull: Slavin MA
      – PersonEntity:
          Name:
            NameFull: Fortún J
      – PersonEntity:
          Name:
            NameFull: Nguyen MH
      – PersonEntity:
          Name:
            NameFull: Patterson TF
      – PersonEntity:
          Name:
            NameFull: Uspenskaya O
      – PersonEntity:
          Name:
            NameFull: Van de Veerdonk FL
      – PersonEntity:
          Name:
            NameFull: Verweij PE
      – PersonEntity:
          Name:
            NameFull: Aoun M
      – PersonEntity:
          Name:
            NameFull: Georgala A
      – PersonEntity:
          Name:
            NameFull: Alexander BD
      – PersonEntity:
          Name:
            NameFull: Chayakulkeeree M
      – PersonEntity:
          Name:
            NameFull: Mehra V
      – PersonEntity:
          Name:
            NameFull: Miceli MH
      – PersonEntity:
          Name:
            NameFull: Sikka MK
      – PersonEntity:
          Name:
            NameFull: Solé A
      – PersonEntity:
          Name:
            NameFull: Walsh TJ
      – PersonEntity:
          Name:
            NameFull: Aguado JM
      – PersonEntity:
          Name:
            NameFull: Holland SM
      – PersonEntity:
          Name:
            NameFull: Moussa M
      – PersonEntity:
          Name:
            NameFull: Rautemaa-Richardson R
      – PersonEntity:
          Name:
            NameFull: Bazaz R
      – PersonEntity:
          Name:
            NameFull: Schwartz S
      – PersonEntity:
          Name:
            NameFull: Walsh SR
      – PersonEntity:
          Name:
            NameFull: Plate M
      – PersonEntity:
          Name:
            NameFull: Yehudai-Ofir D
      – PersonEntity:
          Name:
            NameFull: Brüggemann RJ
      – PersonEntity:
          Name:
            NameFull: Cornely OA
      – PersonEntity:
          Name:
            NameFull: Ostrosky-Zeichner L
      – PersonEntity:
          Name:
            NameFull: Vazquez JA
      – PersonEntity:
          Name:
            NameFull: White PL
      – PersonEntity:
          Name:
            NameFull: Cornelissen K
      – PersonEntity:
          Name:
            NameFull: Ross GG
      – PersonEntity:
          Name:
            NameFull: Fitton L
      – PersonEntity:
          Name:
            NameFull: Dane A
      – PersonEntity:
          Name:
            NameFull: Zinzi D
      – PersonEntity:
          Name:
            NameFull: Rex JH
      – PersonEntity:
          Name:
            NameFull: Chen SC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: 2025 Nov
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1474-4457
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: The Lancet. Infectious diseases
              Type: main
ResultId 1