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In-line NIR spectroscopy for comprehensive process understanding of semi-continuous blending in continuous production of low-dose formulations.

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Title: In-line NIR spectroscopy for comprehensive process understanding of semi-continuous blending in continuous production of low-dose formulations.
Authors: Bouckaert L; Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., De Man A; Laboratory of Pharmaceutical Process Analytical Technology, Department of Analytics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., De Souter L; Laboratory of Pharmaceutical Process Analytical Technology, Department of Analytics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., Starsich F; Gericke AG, Althardstrasse 120, Regensdorf, Switzerland., Meir B; Gericke AG, Althardstrasse 120, Regensdorf, Switzerland., Sowinski S; Sentronic, Gostritzer Str. 61-63, Dresden, Germany., Vervaet C; Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., De Beer T; Laboratory of Pharmaceutical Process Analytical Technology, Department of Analytics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., Vanhoorne V; Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address: valerie.vanhoorne@ugent.be.
Source: International journal of pharmaceutics [Int J Pharm] 2025 Aug 20; Vol. 681, pp. 125622. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In-line NIR spectroscopy for comprehensive process understanding of semi-continuous blending in continuous production of low-dose formulations.
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  Data: <searchLink fieldCode="AU" term="%22Bouckaert+L%22">Bouckaert L</searchLink>; Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Man+A%22">De Man A</searchLink>; Laboratory of Pharmaceutical Process Analytical Technology, Department of Analytics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Souter+L%22">De Souter L</searchLink>; Laboratory of Pharmaceutical Process Analytical Technology, Department of Analytics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Starsich+F%22">Starsich F</searchLink>; Gericke AG, Althardstrasse 120, Regensdorf, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meir+B%22">Meir B</searchLink>; Gericke AG, Althardstrasse 120, Regensdorf, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sowinski+S%22">Sowinski S</searchLink>; Sentronic, Gostritzer Str. 61-63, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Vervaet+C%22">Vervaet C</searchLink>; Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Beer+T%22">De Beer T</searchLink>; Laboratory of Pharmaceutical Process Analytical Technology, Department of Analytics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanhoorne+V%22">Vanhoorne V</searchLink>; Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address: valerie.vanhoorne@ugent.be.
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  Data: <searchLink fieldCode="JN" term="%227804127%22">International journal of pharmaceutics</searchLink> [Int J Pharm] 2025 Aug 20; Vol. 681, pp. 125622. <i>Date of Electronic Publication: </i>2025 Jun 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2FNorth-Holland+Biomedical+Press%22">Elsevier/North-Holland Biomedical Press </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7804127 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-3476 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203785173%22">03785173 </searchLink><i>NLM ISO Abbreviation: </i>Int J Pharm <i>Subsets: </i>MEDLINE
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