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Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.

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Title: Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.
Authors: Gao PY; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China., Fu Y; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China., He XY; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China., Zhang DD; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China., Chi HC; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China., Huang YM; Department of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China., Wang ZB; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China., Zhang W; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China., Ou YN; Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China., Ge YJ; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China., You J; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China., Ma LZ; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China., Qiang YX; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China., Zhao B; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China., Yu HH; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China., Feng J; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200040, China., Tan L; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China. Electronic address: dr.tanlan@163.com., Cheng W; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200040, China. Electronic address: wcheng@fudan.edu.cn., Zhang YR; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address: yaruzhang@fudan.edu.cn., Yu JT; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address: jintai_yu@fudan.edu.cn.
Source: Journal of advanced research [J Adv Res] 2026 Apr; Vol. 82, pp. 685-699. Date of Electronic Publication: 2025 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.
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  Data: <searchLink fieldCode="AU" term="%22Gao+PY%22">Gao PY</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22He+XY%22">He XY</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22Zhang+DD%22">Zhang DD</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Chi+HC%22">Chi HC</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Huang+YM%22">Huang YM</searchLink>; Department of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZB%22">Wang ZB</searchLink>; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Ou+YN%22">Ou YN</searchLink>; Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China.<br /><searchLink fieldCode="AU" term="%22Ge+YJ%22">Ge YJ</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22You+J%22">You J</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Ma+LZ%22">Ma LZ</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Qiang+YX%22">Qiang YX</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22Zhao+B%22">Zhao B</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Yu+HH%22">Yu HH</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Feng+J%22">Feng J</searchLink>; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China. Electronic address: dr.tanlan@163.com.<br /><searchLink fieldCode="AU" term="%22Cheng+W%22">Cheng W</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200040, China. Electronic address: wcheng@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+YR%22">Zhang YR</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address: yaruzhang@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yu+JT%22">Yu JT</searchLink>; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address: jintai_yu@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101546952%22">Journal of advanced research</searchLink> [J Adv Res] 2026 Apr; Vol. 82, pp. 685-699. <i>Date of Electronic Publication: </i>2025 Jun 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cairo+University%2C+production+and+hosting+by+Elsevier+B%2E+V%22">Cairo University, production and hosting by Elsevier B. V </searchLink><i>Country of Publication: </i>Egypt <i>NLM ID: </i>101546952 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2090-1224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220901224%22">20901224 </searchLink><i>NLM ISO Abbreviation: </i>J Adv Res <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jare.2025.06.046
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        Text: English
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              Text: 2026 Apr
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