View in EDS

Current practices on the measurement of electrocardiogram and hemodynamic parameters in non-rodent species in regulatory safety assessment studies.

Saved in:
Bibliographic Details
Title: Current practices on the measurement of electrocardiogram and hemodynamic parameters in non-rodent species in regulatory safety assessment studies.
Authors: Valentin JP; Early Clinical Development & Translational Science, Non-Clinical Safety Evaluation, UCB, Braine L'Alleud, Belgium. Electronic address: jean-pierre.valentin@ucb.com., Bourcier T; Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA.; Todd Bourcier Current Contact Information is 'White Oak Regulatory Tox, LLC, Crownsville, MD 21032, USA.. Electronic address: todd.bourcier@whiteoakregtox.com., Chi X; Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA.. Electronic address: Xuan.Chi@fda.hhs.gov., Delaunois A; Early Clinical Development & Translational Science, Non-Clinical Safety Evaluation, UCB, Braine L'Alleud, Belgium. Electronic address: annie.delaunois@ucb.com., Foley CM; Preclinical Safety/Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, USA.. Electronic address: michael.foley@abbvie.com., Henderson KA; Amgen Research, Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA 91320, USA.. Electronic address: khende02@amgen.com., Lainee P; Sanofi Research and Development, Translational Models, Montpellier, France.. Electronic address: pierre.lainee@sanofi.com., Leishman DJ; Drug Disposition, Toxicology and PKPD, Eli Lilly and Company, Indianapolis, IN 46285, USA.. Electronic address: derek.leishman@lilly.com., Li D; Pfizer Research and Development, Eastern Point Road, Groton, CT 06340, USA.. Electronic address: dingzhou.li@pfizer.com., Pawluk E; Early Clinical Development & Translational Science, Non-Clinical Safety Evaluation, UCB, Braine L'Alleud, Belgium. Electronic address: emma.pawluk@ucb.com., Pugsley MK; Cytokinetics, Toxicology & Safety Pharmacology, South San Francisco, CA 85024, USA.. Electronic address: mpugsley@cytokinetics.com., Rajamani S; Johnson & Johnson Innovative Medicine, 3120 Merryfield Row, San Diego, CA 92121, USA.. Electronic address: srajama3@its.jnj.com., Regan CP; Nonclinical Drug Safety Merck & Co., Inc., Rahway, NJ 07065, USA.. Electronic address: christopher_regan@merck.com., Rolf MG; AstraZeneca R&D, Pepparedsleden 1, 431 83 Mölndal, Sweden. Electronic address: mike.rolf@astrazeneca.com., Ross R; Labcorp, Madison, WI 53704, USA.. Electronic address: rebecca.ross@labcorp.com., Rossman EI; GSK, Safety Pharmacology, Collegeville, PA 19426, USA.. Electronic address: eric.i.rossman@gsk.com., Tichenor SD; Charles River Laboratories, 6995 Longley Lane, Reno, NV 89511, USA.. Electronic address: steve.tichenor@crl.com., Villar IC; AstraZeneca R&D, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB20AA, UK. Electronic address: conchi.villarmoas@astrazeneca.com., Wisialowski TA; Pfizer Research and Development, Eastern Point Road, Groton, CT 06340, USA.. Electronic address: todd.a.wisialowski@pfizer.com., Wu J; Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA.. Electronic address: jean.wu@fda.hhs.gov., Vargas HM; Amgen Research, Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA 91320, USA.. Electronic address: hvargas@amgen.com.
Source: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2025 Sep; Vol. 135, pp. 107765. Date of Electronic Publication: 2025 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9206091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-488X (Electronic) Linking ISSN: 10568719 NLM ISO Abbreviation: J Pharmacol Toxicol Methods Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40543904
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Current practices on the measurement of electrocardiogram and hemodynamic parameters in non-rodent species in regulatory safety assessment studies.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Valentin+JP%22">Valentin JP</searchLink>; Early Clinical Development & Translational Science, Non-Clinical Safety Evaluation, UCB, Braine L'Alleud, Belgium. Electronic address: jean-pierre.valentin@ucb.com.<br /><searchLink fieldCode="AU" term="%22Bourcier+T%22">Bourcier T</searchLink>; Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA.; Todd Bourcier Current Contact Information is 'White Oak Regulatory Tox, LLC, Crownsville, MD 21032, USA.. Electronic address: todd.bourcier@whiteoakregtox.com.<br /><searchLink fieldCode="AU" term="%22Chi+X%22">Chi X</searchLink>; Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA.. Electronic address: Xuan.Chi@fda.hhs.gov.<br /><searchLink fieldCode="AU" term="%22Delaunois+A%22">Delaunois A</searchLink>; Early Clinical Development & Translational Science, Non-Clinical Safety Evaluation, UCB, Braine L'Alleud, Belgium. Electronic address: annie.delaunois@ucb.com.<br /><searchLink fieldCode="AU" term="%22Foley+CM%22">Foley CM</searchLink>; Preclinical Safety/Safety Pharmacology, AbbVie Inc., North Chicago, IL 60064, USA.. Electronic address: michael.foley@abbvie.com.<br /><searchLink fieldCode="AU" term="%22Henderson+KA%22">Henderson KA</searchLink>; Amgen Research, Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA 91320, USA.. Electronic address: khende02@amgen.com.<br /><searchLink fieldCode="AU" term="%22Lainee+P%22">Lainee P</searchLink>; Sanofi Research and Development, Translational Models, Montpellier, France.. Electronic address: pierre.lainee@sanofi.com.<br /><searchLink fieldCode="AU" term="%22Leishman+DJ%22">Leishman DJ</searchLink>; Drug Disposition, Toxicology and PKPD, Eli Lilly and Company, Indianapolis, IN 46285, USA.. Electronic address: derek.leishman@lilly.com.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Pfizer Research and Development, Eastern Point Road, Groton, CT 06340, USA.. Electronic address: dingzhou.li@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Pawluk+E%22">Pawluk E</searchLink>; Early Clinical Development & Translational Science, Non-Clinical Safety Evaluation, UCB, Braine L'Alleud, Belgium. Electronic address: emma.pawluk@ucb.com.<br /><searchLink fieldCode="AU" term="%22Pugsley+MK%22">Pugsley MK</searchLink>; Cytokinetics, Toxicology & Safety Pharmacology, South San Francisco, CA 85024, USA.. Electronic address: mpugsley@cytokinetics.com.<br /><searchLink fieldCode="AU" term="%22Rajamani+S%22">Rajamani S</searchLink>; Johnson & Johnson Innovative Medicine, 3120 Merryfield Row, San Diego, CA 92121, USA.. Electronic address: srajama3@its.jnj.com.<br /><searchLink fieldCode="AU" term="%22Regan+CP%22">Regan CP</searchLink>; Nonclinical Drug Safety Merck & Co., Inc., Rahway, NJ 07065, USA.. Electronic address: christopher_regan@merck.com.<br /><searchLink fieldCode="AU" term="%22Rolf+MG%22">Rolf MG</searchLink>; AstraZeneca R&D, Pepparedsleden 1, 431 83 Mölndal, Sweden. Electronic address: mike.rolf@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Ross+R%22">Ross R</searchLink>; Labcorp, Madison, WI 53704, USA.. Electronic address: rebecca.ross@labcorp.com.<br /><searchLink fieldCode="AU" term="%22Rossman+EI%22">Rossman EI</searchLink>; GSK, Safety Pharmacology, Collegeville, PA 19426, USA.. Electronic address: eric.i.rossman@gsk.com.<br /><searchLink fieldCode="AU" term="%22Tichenor+SD%22">Tichenor SD</searchLink>; Charles River Laboratories, 6995 Longley Lane, Reno, NV 89511, USA.. Electronic address: steve.tichenor@crl.com.<br /><searchLink fieldCode="AU" term="%22Villar+IC%22">Villar IC</searchLink>; AstraZeneca R&D, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB20AA, UK. Electronic address: conchi.villarmoas@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Wisialowski+TA%22">Wisialowski TA</searchLink>; Pfizer Research and Development, Eastern Point Road, Groton, CT 06340, USA.. Electronic address: todd.a.wisialowski@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA.. Electronic address: jean.wu@fda.hhs.gov.<br /><searchLink fieldCode="AU" term="%22Vargas+HM%22">Vargas HM</searchLink>; Amgen Research, Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA 91320, USA.. Electronic address: hvargas@amgen.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229206091%22">Journal of pharmacological and toxicological methods</searchLink> [J Pharmacol Toxicol Methods] 2025 Sep; Vol. 135, pp. 107765. <i>Date of Electronic Publication: </i>2025 Jun 19.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9206091 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-488X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210568719%22">10568719 </searchLink><i>NLM ISO Abbreviation: </i>J Pharmacol Toxicol Methods <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40543904
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.vascn.2025.107765
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 107765
    Titles:
      – TitleFull: Current practices on the measurement of electrocardiogram and hemodynamic parameters in non-rodent species in regulatory safety assessment studies.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Valentin JP
      – PersonEntity:
          Name:
            NameFull: Bourcier T
      – PersonEntity:
          Name:
            NameFull: Chi X
      – PersonEntity:
          Name:
            NameFull: Delaunois A
      – PersonEntity:
          Name:
            NameFull: Foley CM
      – PersonEntity:
          Name:
            NameFull: Henderson KA
      – PersonEntity:
          Name:
            NameFull: Lainee P
      – PersonEntity:
          Name:
            NameFull: Leishman DJ
      – PersonEntity:
          Name:
            NameFull: Li D
      – PersonEntity:
          Name:
            NameFull: Pawluk E
      – PersonEntity:
          Name:
            NameFull: Pugsley MK
      – PersonEntity:
          Name:
            NameFull: Rajamani S
      – PersonEntity:
          Name:
            NameFull: Regan CP
      – PersonEntity:
          Name:
            NameFull: Rolf MG
      – PersonEntity:
          Name:
            NameFull: Ross R
      – PersonEntity:
          Name:
            NameFull: Rossman EI
      – PersonEntity:
          Name:
            NameFull: Tichenor SD
      – PersonEntity:
          Name:
            NameFull: Villar IC
      – PersonEntity:
          Name:
            NameFull: Wisialowski TA
      – PersonEntity:
          Name:
            NameFull: Wu J
      – PersonEntity:
          Name:
            NameFull: Vargas HM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: 2025 Sep
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1873-488X
          Numbering:
            – Type: volume
              Value: 135
          Titles:
            – TitleFull: Journal of pharmacological and toxicological methods
              Type: main
ResultId 1