Obecabtagene autoleucel, a novel CD19-directed CAR T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: the future for reducing toxicity and T-cell exhaustion?

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Title: Obecabtagene autoleucel, a novel CD19-directed CAR T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: the future for reducing toxicity and T-cell exhaustion?
Authors: Yared JA; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA., Fromowitz A; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA., Kocoglu M; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA., Hardy N; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA., Atanackovic D; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA., Rapoport AP; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.
Source: Expert review of hematology [Expert Rev Hematol] 2025 Aug; Vol. 18 (8), pp. 585-593. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article; Review
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Obecabtagene autoleucel, a novel CD19-directed CAR T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: the future for reducing toxicity and T-cell exhaustion?
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  Data: <searchLink fieldCode="AU" term="%22Yared+JA%22">Yared JA</searchLink>; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fromowitz+A%22">Fromowitz A</searchLink>; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kocoglu+M%22">Kocoglu M</searchLink>; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hardy+N%22">Hardy N</searchLink>; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Atanackovic+D%22">Atanackovic D</searchLink>; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rapoport+AP%22">Rapoport AP</searchLink>; Department of Medicine, Division of Hematology/Oncology, Transplant & Cellular Therapy Program, Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA.
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  Data: <searchLink fieldCode="JN" term="%22101485942%22">Expert review of hematology</searchLink> [Expert Rev Hematol] 2025 Aug; Vol. 18 (8), pp. 585-593. <i>Date of Electronic Publication: </i>2025 Jun 24.
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        Value: 10.1080/17474086.2025.2523551
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      – TitleFull: Obecabtagene autoleucel, a novel CD19-directed CAR T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: the future for reducing toxicity and T-cell exhaustion?
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              Text: 2025 Aug
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