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Predicting resistance to chemotherapy using chromosomal instability signatures.

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Title: Predicting resistance to chemotherapy using chromosomal instability signatures.
Authors: Thompson JS; Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Tailor Bio Ltd, Cambridge, UK., Madrid L; Tailor Bio Ltd, Cambridge, UK., Hernando B; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Sauer CM; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Vias M; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Escobar-Rey M; Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Tailor Bio Ltd, Cambridge, UK., Leung WK; Tailor Bio Ltd, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Garcia-Lopez D; Tailor Bio Ltd, Cambridge, UK., Huckstep J; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Sekowska M; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Hosking K; Department of Oncology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Jimenez-Linan M; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Cancer Research UK Major Centre Cambridge, University of Cambridge, Cambridge, UK., Reinius MAV; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Cancer Research UK Major Centre Cambridge, University of Cambridge, Cambridge, UK., Roy A; Tailor Bio Ltd, Cambridge, UK., Abdulle O; Tailor Bio Ltd, Cambridge, UK., Pangonyte J; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Dobson H; Tailor Bio Ltd, Cambridge, UK., Cullen AE; Tailor Bio Ltd, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., De Silva D; Tailor Bio Ltd, Cambridge, UK., Gómez-Sánchez D; Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; H12O-CNIO Lung Cancer Clinical Research Unit, Health Research Institute Hospital 12 de Octubre, Madrid, Spain., Torres M; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Fernández-Sanromán Á; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Sanders D; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Martins FC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Cancer Research UK Major Centre Cambridge, University of Cambridge, Cambridge, UK.; Institute for Women's Health, University College London, University College London Hospitals Biomedical Research Centre, London, UK., Funingana IG; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Codacci-Pisanelli G; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.; Early Phase Clinical Trials Team, Department of Oncology, University of Cambridge, Cambridge, UK., Quintela-Fandino M; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Markowetz F; Tailor Bio Ltd, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Cambridge, UK., Yip J; Tailor Bio Ltd, Cambridge, UK., Brenton JD; Tailor Bio Ltd, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Cancer Research UK Major Centre Cambridge, University of Cambridge, Cambridge, UK., Piskorz AM; Tailor Bio Ltd, Cambridge, UK. anna.piskorz@cruk.cam.ac.uk.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. anna.piskorz@cruk.cam.ac.uk., Macintyre G; Spanish National Cancer Research Centre (CNIO), Madrid, Spain. gmacintyre@cnio.es.; Tailor Bio Ltd, Cambridge, UK. gmacintyre@cnio.es.
Source: Nature genetics [Nat Genet] 2025 Jul; Vol. 57 (7), pp. 1708-1717. Date of Electronic Publication: 2025 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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Tailor Bio Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Brenton+JD%22">Brenton JD</searchLink>; Tailor Bio Ltd, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Cancer Research UK Major Centre Cambridge, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Piskorz+AM%22">Piskorz AM</searchLink>; Tailor Bio Ltd, Cambridge, UK. anna.piskorz@cruk.cam.ac.uk.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. anna.piskorz@cruk.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Macintyre+G%22">Macintyre G</searchLink>; Spanish National Cancer Research Centre (CNIO), Madrid, Spain. gmacintyre@cnio.es.; Tailor Bio Ltd, Cambridge, UK. gmacintyre@cnio.es.
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