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Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method.

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Title: Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method.
Authors: Choi K; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Lee JY; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Kim UI; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Park SH; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea., Hong SH; Department of Microbiology, College of Medicine, Ewha Womens University, Seoul, Republic of Korea., Bang YJ; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon-si, Republic of Korea., Hwang YH; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea., Lee JE; Department of Life Science, Sogang University, Seoul, Republic of Korea., Park S; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Kim S; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea., Lee S; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Yun YJ; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Uhm TG; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Lee I; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Kwon M; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Kwon E; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Song S; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Kweon Y; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Kim H; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Oh EY; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea., Kim JY; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon-si, Republic of Korea., Lee TY; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea., Kim SY; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea., Kim SE; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea., Kim YJ; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea., Lee S; Department of Life Science, Sogang University, Seoul, Republic of Korea., Sun R; Department of Life Science, Sogang University, Seoul, Republic of Korea., Lee EJ; Department of Life Science, Sogang University, Seoul, Republic of Korea., Kim G; Department of Life Science, Sogang University, Seoul, Republic of Korea., Lim H; Department of Life Science, Sogang University, Seoul, Republic of Korea., Kim B; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Kim J; Department of Life Science, Sogang University, Seoul, Republic of Korea., Kim D; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea., Nam JH; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon-si, Republic of Korea., Lee SM; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea., Kim K; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea., Yang JS; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Source: Frontiers in immunology [Front Immunol] 2025 Jun 09; Vol. 16, pp. 1571713. Date of Electronic Publication: 2025 Jun 09 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method.
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  Data: <searchLink fieldCode="AU" term="%22Choi+K%22">Choi K</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+UI%22">Kim UI</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hong+SH%22">Hong SH</searchLink>; Department of Microbiology, College of Medicine, Ewha Womens University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Bang+YJ%22">Bang YJ</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hwang+YH%22">Hwang YH</searchLink>; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JE%22">Lee JE</searchLink>; Department of Life Science, Sogang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yun+YJ%22">Yun YJ</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Uhm+TG%22">Uhm TG</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+I%22">Lee I</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+M%22">Kwon M</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+E%22">Kwon E</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+S%22">Song S</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kweon+Y%22">Kweon Y</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+EY%22">Oh EY</searchLink>; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JY%22">Kim JY</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+TY%22">Lee TY</searchLink>; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SY%22">Kim SY</searchLink>; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SE%22">Kim SE</searchLink>; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YJ%22">Kim YJ</searchLink>; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Life Science, Sogang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sun+R%22">Sun R</searchLink>; Department of Life Science, Sogang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+EJ%22">Lee EJ</searchLink>; Department of Life Science, Sogang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+G%22">Kim G</searchLink>; Department of Life Science, Sogang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+H%22">Lim H</searchLink>; Department of Life Science, Sogang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+B%22">Kim B</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Life Science, Sogang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Nam+JH%22">Nam JH</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SM%22">Lee SM</searchLink>; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yang+JS%22">Yang JS</searchLink>; R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 Jun 09; Vol. 16, pp. 1571713. <i>Date of Electronic Publication: </i>2025 Jun 09 (<i>Print Publication: </i>2025).
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