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MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models.

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Title: MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models.
Authors: Zhang X; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Borcherding DC; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Zhang M; Tango Therapeutics, Boston, Massachusetts., Lyu Y; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Wang G; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., He K; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Oztosun G; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Sachdeva I; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Yang L; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Yang K; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Yuen A; Tango Therapeutics, Boston, Massachusetts., DiBenedetto H; Tango Therapeutics, Boston, Massachusetts., Tsai A; Tango Therapeutics, Boston, Massachusetts., Huang A; Tango Therapeutics, Boston, Massachusetts., Maxwell JP; Tango Therapeutics, Boston, Massachusetts., Cottrell KM; Tango Therapeutics, Boston, Massachusetts., Briggs KJ; Tango Therapeutics, Boston, Massachusetts., Hirbe AC; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Nov 14; Vol. 31 (22), pp. 4779-4789.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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              Text: 2025 Nov 14
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