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Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice.

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Title: Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice.
Authors: da Rocha AL; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Pinto AP; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., de Sousa Neto IV; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Muñoz VR; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Marafon BB; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., da Silva LECM; Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Pauli JR; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil., Cintra DE; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil., Ropelle ER; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil., Simabuco FM; Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil., de Moura LP; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil., de Freitas EC; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Rivas DA; Center for Exercise Medicine Research, Fralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, USA., da Silva ASR; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Source: The Journal of physiology [J Physiol] 2025 Jul; Vol. 603 (14), pp. 3923-3944. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice.
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  Data: <searchLink fieldCode="AU" term="%22da+Rocha+AL%22">da Rocha AL</searchLink>; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinto+AP%22">Pinto AP</searchLink>; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+Neto+IV%22">de Sousa Neto IV</searchLink>; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Muñoz+VR%22">Muñoz VR</searchLink>; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Marafon+BB%22">Marafon BB</searchLink>; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+LECM%22">da Silva LECM</searchLink>; Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pauli+JR%22">Pauli JR</searchLink>; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cintra+DE%22">Cintra DE</searchLink>; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Ropelle+ER%22">Ropelle ER</searchLink>; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Simabuco+FM%22">Simabuco FM</searchLink>; Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Moura+LP%22">de Moura LP</searchLink>; School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Freitas+EC%22">de Freitas EC</searchLink>; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Rivas+DA%22">Rivas DA</searchLink>; Center for Exercise Medicine Research, Fralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, USA.<br /><searchLink fieldCode="AU" term="%22da+Silva+ASR%22">da Silva ASR</searchLink>; Department of Health Sciences, Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.; School of Physical Education and Sport of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
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  Data: <searchLink fieldCode="JN" term="%220266262%22">The Journal of physiology</searchLink> [J Physiol] 2025 Jul; Vol. 603 (14), pp. 3923-3944. <i>Date of Electronic Publication: </i>2025 Jun 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cambridge+Univ%2E+Press%22">Cambridge Univ. Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0266262 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-7793 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223751%22">00223751 </searchLink><i>NLM ISO Abbreviation: </i>J Physiol <i>Subsets: </i>MEDLINE
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      – TitleFull: Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice.
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              Text: 2025 Jul
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