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Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism.

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Title: Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism.
Authors: Lee TJ; John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.; Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Santeford A; John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Pitts KM; John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Ripoll CV; Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Terao R; John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.; Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Guo Z; Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Ozcan M; Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Kratky D; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria., Christoffersen C; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Javaheri A; Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. ali.javaheri@wustl.edu.; John Cochran VA Hospital, St Louis, MO, USA. ali.javaheri@wustl.edu., Apte RS; John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. apte@wustl.edu.; Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. apte@wustl.edu.
Source: Nature communications [Nat Commun] 2025 Jun 24; Vol. 16 (1), pp. 5331. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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