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Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.

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Title: Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.
Authors: Bradley J; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Pottier C; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., da Fonseca EL; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. MacDonald Foundation Department of Human Genetics, University of Miami, Coral Gables, Florida, USA., Kurup JT; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Western D; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Wang C; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Neupane A; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Ray NR; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Jean-Francois M; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Ali M; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Timsina J; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Bergmann K; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Budde J; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA., Martin ER; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. MacDonald Foundation Department of Human Genetics, University of Miami, Coral Gables, Florida, USA., Pericak-Vance MA; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. MacDonald Foundation Department of Human Genetics, University of Miami, Coral Gables, Florida, USA., Cuccaro M; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Naj AC; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kunkle BW; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Fernandez V; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA.; Fundacio ACE Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Haines J; Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Morris JC; Department of Neurology, Washington University School in St. Louis, St. Louis, Missouri, USA.; Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA., Holtzman DM; Department of Neurology, Washington University School in St. Louis, St. Louis, Missouri, USA.; Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, Missouri, USA., Perrin RJ; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA., Reitz C; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Beecham GW; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Cruchaga C; NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St Louis, Missouri, USA.
Corporate Authors: Alzheimer's Disease Genetics Consortium (ADGC), Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight‐ADRC)
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Jun; Vol. 21 (6), pp. e70377.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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