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pH-sensor GPR68 plays a role in how dietary fibre lowers blood pressure in a preclinical model of hypertension.

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Title: pH-sensor GPR68 plays a role in how dietary fibre lowers blood pressure in a preclinical model of hypertension.
Authors: Dinakis E; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia., Xu C; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia., R Muralitharan R; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia., Jama H; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia., Xie L; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Precision Medicine Translational Research Programme, Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Leung KC; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia., Mirabito Colafella KM; Cardiovascular Disease Program, Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia., McArdle Z; Cardiovascular Disease Program, Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia., Salimova E; Monash Bioimaging Facility, Monash University, Melbourne, Australia., Camargo Tavares L; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia., Snelson M; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia., Johnson C; Bioimaging Platform, La Trobe University, Melbourne, Australia., Gaspari T; IRAP Pharmacology Group, Department of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia., Mackay CR; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China., O'Donnell JA; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia., Marques FZ; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia.
Source: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2025 Oct 28; Vol. 139 (21). Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Electronic Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE
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  Data: pH-sensor GPR68 plays a role in how dietary fibre lowers blood pressure in a preclinical model of hypertension.
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  Data: <searchLink fieldCode="AU" term="%22Dinakis+E%22">Dinakis E</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22R+Muralitharan+R%22">R Muralitharan R</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Jama+H%22">Jama H</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; Precision Medicine Translational Research Programme, Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Leung+KC%22">Leung KC</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Mirabito+Colafella+KM%22">Mirabito Colafella KM</searchLink>; Cardiovascular Disease Program, Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22McArdle+Z%22">McArdle Z</searchLink>; Cardiovascular Disease Program, Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Salimova+E%22">Salimova E</searchLink>; Monash Bioimaging Facility, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Camargo+Tavares+L%22">Camargo Tavares L</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Snelson+M%22">Snelson M</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Johnson+C%22">Johnson C</searchLink>; Bioimaging Platform, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Gaspari+T%22">Gaspari T</searchLink>; IRAP Pharmacology Group, Department of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Mackay+CR%22">Mackay CR</searchLink>; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.; School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.<br /><searchLink fieldCode="AU" term="%22O'Donnell+JA%22">O'Donnell JA</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Marques+FZ%22">Marques FZ</searchLink>; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.; Victorian Heart Institute, Monash University, Melbourne, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia.
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