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Enhancement of tacrolimus production in Streptomyces tsukubaensis by genetic engineering and process optimization.

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Title: Enhancement of tacrolimus production in Streptomyces tsukubaensis by genetic engineering and process optimization.
Authors: Zhang J; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China., Huang H; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China., Zhang Z; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, 826 Zhangheng Road, Pudong, Shanghai, 201203, P. R. China., Tang J; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China., Gui J; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China., Yang S; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China., Chen S; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China. sxzlb@263.net.
Source: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2025 Jun 25; Vol. 41 (7), pp. 224. Date of Electronic Publication: 2025 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9012472 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0972 (Electronic) Linking ISSN: 09593993 NLM ISO Abbreviation: World J Microbiol Biotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhancement of tacrolimus production in Streptomyces tsukubaensis by genetic engineering and process optimization.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, 826 Zhangheng Road, Pudong, Shanghai, 201203, P. R. China.<br /><searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China.<br /><searchLink fieldCode="AU" term="%22Gui+J%22">Gui J</searchLink>; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; National Key Laboratory of Lead Druggability Research, China State Institute of Pharmaceutical Industry, Shanghai Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai, 201203, P. R. China. sxzlb@263.net.
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        Value: 10.1007/s11274-025-04410-x
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              Text: 2025 Jun 25
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