Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses.
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| Title: | Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses. |
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| Authors: | Lakshmipathi J; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Santha S; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Li M; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Qian Y; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Roy SF; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.; Department of Pathology, McGill University, Montreal, Canada., Luheshi N; AstraZeneca, Cambridge Biomedical Campus, Cambridge, CB2 0AA, UK., Politi K; Departments of Pathology and Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Bosenberg M; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Departments of Pathology and Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Eyles J; AstraZeneca, Cambridge Biomedical Campus, Cambridge, CB2 0AA, UK., Muthusamy V; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. vish.muthusamy@yale.edu.; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT, USA. vish.muthusamy@yale.edu. |
| Source: | Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Jun 25; Vol. 74 (8), pp. 250. Date of Electronic Publication: 2025 Jun 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0851 |
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| DOI: | 10.1007/s00262-025-04105-0 |
