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Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses.

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Title: Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses.
Authors: Lakshmipathi J; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Santha S; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Li M; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Qian Y; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Roy SF; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.; Department of Pathology, McGill University, Montreal, Canada., Luheshi N; AstraZeneca, Cambridge Biomedical Campus, Cambridge, CB2 0AA, UK., Politi K; Departments of Pathology and Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Bosenberg M; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Departments of Pathology and Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Eyles J; AstraZeneca, Cambridge Biomedical Campus, Cambridge, CB2 0AA, UK., Muthusamy V; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. vish.muthusamy@yale.edu.; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT, USA. vish.muthusamy@yale.edu.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Jun 25; Vol. 74 (8), pp. 250. Date of Electronic Publication: 2025 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses.
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  Data: <searchLink fieldCode="AU" term="%22Lakshmipathi+J%22">Lakshmipathi J</searchLink>; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Santha+S%22">Santha S</searchLink>; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Qian+Y%22">Qian Y</searchLink>; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Roy+SF%22">Roy SF</searchLink>; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.; Department of Pathology, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Luheshi+N%22">Luheshi N</searchLink>; AstraZeneca, Cambridge Biomedical Campus, Cambridge, CB2 0AA, UK.<br /><searchLink fieldCode="AU" term="%22Politi+K%22">Politi K</searchLink>; Departments of Pathology and Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Bosenberg+M%22">Bosenberg M</searchLink>; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Departments of Pathology and Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Eyles+J%22">Eyles J</searchLink>; AstraZeneca, Cambridge Biomedical Campus, Cambridge, CB2 0AA, UK.<br /><searchLink fieldCode="AU" term="%22Muthusamy+V%22">Muthusamy V</searchLink>; Yale Center for Precision Cancer Modeling, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. vish.muthusamy@yale.edu.; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT, USA. vish.muthusamy@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%228605732%22">Cancer immunology, immunotherapy : CII</searchLink> [Cancer Immunol Immunother] 2025 Jun 25; Vol. 74 (8), pp. 250. <i>Date of Electronic Publication: </i>2025 Jun 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8605732 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0851 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203407004%22">03407004 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Immunother <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40560386
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              Text: 2025 Jun 25
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