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Elexacaftor/tezacaftor/ivacaftor (ETI) therapy modifies the expression of interferon beta and inflammatory genes in the airways of adult patients with cystic fibrosis: a pilot study.

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Title: Elexacaftor/tezacaftor/ivacaftor (ETI) therapy modifies the expression of interferon beta and inflammatory genes in the airways of adult patients with cystic fibrosis: a pilot study.
Authors: Bitossi C; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy. camilla.bitossi@uniroma1.it., Frasca F; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy., D'Auria A; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy., Fracella M; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy., Radocchia G; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, 00185, Rome, Italy., Trancassini M; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, 00185, Rome, Italy., Petrarca L; Department of Maternal, Infantile and Urological Sciences, 'Sapienza' University of Rome, 00161, Rome, Italy., La Regina D; Department of Maternal, Infantile and Urological Sciences, 'Sapienza' University of Rome, 00161, Rome, Italy., Troiani P; Lazio Reference Center for Cystic Fibrosis, Hospital 'Policlinico Umberto I', 'Sapienza' University of Rome, 00161, Rome, Italy., Gentile M; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy., Pietropaolo V; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, 00185, Rome, Italy., Midulla F; Department of Maternal, Infantile and Urological Sciences, 'Sapienza' University of Rome, 00161, Rome, Italy., Cimino G; Lazio Reference Center for Cystic Fibrosis, Hospital 'Policlinico Umberto I', 'Sapienza' University of Rome, 00161, Rome, Italy., Antonelli G; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.; Microbiology and Virology Unit, Hospital 'Policlinico Umberto I', 'Sapienza' University of Rome, 00185, Rome, Italy., Pierangeli A; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy., Scagnolari C; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.
Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2025 Oct; Vol. 480 (10), pp. 5521-5529. Date of Electronic Publication: 2025 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
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  Data: Elexacaftor/tezacaftor/ivacaftor (ETI) therapy modifies the expression of interferon beta and inflammatory genes in the airways of adult patients with cystic fibrosis: a pilot study.
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  Data: <searchLink fieldCode="AU" term="%22Bitossi+C%22">Bitossi C</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy. camilla.bitossi@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Frasca+F%22">Frasca F</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Auria+A%22">D'Auria A</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fracella+M%22">Fracella M</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Radocchia+G%22">Radocchia G</searchLink>; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Trancassini+M%22">Trancassini M</searchLink>; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Petrarca+L%22">Petrarca L</searchLink>; Department of Maternal, Infantile and Urological Sciences, 'Sapienza' University of Rome, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22La+Regina+D%22">La Regina D</searchLink>; Department of Maternal, Infantile and Urological Sciences, 'Sapienza' University of Rome, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Troiani+P%22">Troiani P</searchLink>; Lazio Reference Center for Cystic Fibrosis, Hospital 'Policlinico Umberto I', 'Sapienza' University of Rome, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gentile+M%22">Gentile M</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pietropaolo+V%22">Pietropaolo V</searchLink>; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Midulla+F%22">Midulla F</searchLink>; Department of Maternal, Infantile and Urological Sciences, 'Sapienza' University of Rome, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cimino+G%22">Cimino G</searchLink>; Lazio Reference Center for Cystic Fibrosis, Hospital 'Policlinico Umberto I', 'Sapienza' University of Rome, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Antonelli+G%22">Antonelli G</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.; Microbiology and Virology Unit, Hospital 'Policlinico Umberto I', 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pierangeli+A%22">Pierangeli A</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Scagnolari+C%22">Scagnolari C</searchLink>; Virology Laboratory, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, 'Sapienza' University of Rome, 00185, Rome, Italy.
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