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Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules.

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Title: Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules.
Authors: Stevenson A; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland., Staats R; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Dear AJ; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland., Voderholzer D; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland., Dreier JE; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark., Meisl G; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Guido R; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland., Knowles TPJ; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Galvagnion C; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark., Buell AK; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby 2800, Denmark., Vendruscolo M; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Michaels TCT; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul; Vol. 122 (26), pp. e2422427122. Date of Electronic Publication: 2025 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Stevenson+A%22">Stevenson A</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland.<br /><searchLink fieldCode="AU" term="%22Staats+R%22">Staats R</searchLink>; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dear+AJ%22">Dear AJ</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland.<br /><searchLink fieldCode="AU" term="%22Voderholzer+D%22">Voderholzer D</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dreier+JE%22">Dreier JE</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.<br /><searchLink fieldCode="AU" term="%22Meisl+G%22">Meisl G</searchLink>; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Guido+R%22">Guido R</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland.<br /><searchLink fieldCode="AU" term="%22Knowles+TPJ%22">Knowles TPJ</searchLink>; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Galvagnion+C%22">Galvagnion C</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.<br /><searchLink fieldCode="AU" term="%22Buell+AK%22">Buell AK</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby 2800, Denmark.<br /><searchLink fieldCode="AU" term="%22Vendruscolo+M%22">Vendruscolo M</searchLink>; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Michaels+TCT%22">Michaels TCT</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Jul; Vol. 122 (26), pp. e2422427122. <i>Date of Electronic Publication: </i>2025 Jun 25.
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