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Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML.

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Title: Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML.
Authors: Damaskou A; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Wilson R; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Gozdecka M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Giotopoulos G; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Asby R; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Eleftheriou M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Milner Therapeutics Institute, University of Cambridge, Cambridge, United Kingdom., Gu M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Récher C; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.; Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France., Mansat-De Mas V; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.; Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France., Vergez F; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.; Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France., Sahal A; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France., Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.; German Cancer Consortium, Partner Site Munich, Munich, Germany., Papachristou EK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Sawle A; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Yankova E; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Milner Therapeutics Institute, University of Cambridge, Cambridge, United Kingdom., Dudek M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Liu X; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Russell J; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Rak J; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Hilcenko C; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Department of Infectious Disease, Imperial College London, London, United Kingdom., D'Santos C; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.; German Cancer Consortium, Partner Site Munich, Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University, Munich, Germany., Sarry JE; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France., Tzelepis K; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Milner Therapeutics Institute, University of Cambridge, Cambridge, United Kingdom., Huntly BJP; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Warren AJ; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Tavana O; Hematology R&D, AstraZeneca, Waltham, MA., Vassiliou GS; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.
Source: Blood [Blood] 2025 Sep 04; Vol. 146 (10), pp. 1239-1252.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML.
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  Data: <searchLink fieldCode="AU" term="%22Damaskou+A%22">Damaskou A</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wilson+R%22">Wilson R</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Giotopoulos+G%22">Giotopoulos G</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Asby+R%22">Asby R</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Eleftheriou+M%22">Eleftheriou M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Milner Therapeutics Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gu+M%22">Gu M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Récher+C%22">Récher C</searchLink>; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.; Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Mansat-De+Mas+V%22">Mansat-De Mas V</searchLink>; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.; Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Vergez+F%22">Vergez F</searchLink>; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.; Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Sahal+A%22">Sahal A</searchLink>; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Vick+B%22">Vick B</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.; German Cancer Consortium, Partner Site Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Papachristou+EK%22">Papachristou EK</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sawle+A%22">Sawle A</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yankova+E%22">Yankova E</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Milner Therapeutics Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dudek+M%22">Dudek M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Russell+J%22">Russell J</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rak+J%22">Rak J</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hilcenko+C%22">Hilcenko C</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Department of Infectious Disease, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22D'Santos+C%22">D'Santos C</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jeremias+I%22">Jeremias I</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.; German Cancer Consortium, Partner Site Munich, Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sarry+JE%22">Sarry JE</searchLink>; Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, INSERM U1037, Centre National de la Recherche Scientifique U5077, Toulouse, France.; LabEx Toucan, Toulouse, France.; Équipe Labellisée Ligue Nationale Contre le Cancer 2023, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Tzelepis+K%22">Tzelepis K</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Milner Therapeutics Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huntly+BJP%22">Huntly BJP</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Warren+AJ%22">Warren AJ</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tavana+O%22">Tavana O</searchLink>; Hematology R&D, AstraZeneca, Waltham, MA.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.
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