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Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial-Sildenafil Administration to Treat Neonatal Encephalopathy-Study 02.

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Title: Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial-Sildenafil Administration to Treat Neonatal Encephalopathy-Study 02.
Authors: Wintermark P; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada. Electronic address: pia.wintermark@gmail.com., Lapointe A; Division of Neonatology, Sainte-Justine Hospital, University of Montreal, Montreal, QC, Canada., Altit G; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada., Steinhorn R; Department of Pediatrics, Rady Children's Hospital and University of California San Diego, San Diego, CA., Rampakakis E; Department of Pediatrics, McGill University, Montreal, Canada; JSS Medical Research, Montreal, QC, Canada., Meid AD; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany., Burhenne J; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany., Bajraktari-Sylejmani G; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany., Khairy M; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada., Adamo MT; Pharmacy Department, McGill University Health Centre, Montreal, Canada., Gilbert G; MR Clinical Science, Philips Healthcare, Mississauga, ON, Canada., Toffoli D; Department of Ophthalmology, McGill University, Montreal, Canada., Zavalkoff S; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada; Division of Pediatric Critical Care Medicine, Department of Pediatrics, McGill University, Montreal, Canada., Luu TM; Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Montreal, QC, Canada., Hailu E; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada., Haefeli WE; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
Source: The Journal of pediatrics [J Pediatr] 2025 Oct; Vol. 285, pp. 114701. Date of Electronic Publication: 2025 Jun 23.
Publication Type: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 0375410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6833 (Electronic) Linking ISSN: 00223476 NLM ISO Abbreviation: J Pediatr Subsets: MEDLINE
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  Data: Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial-Sildenafil Administration to Treat Neonatal Encephalopathy-Study 02.
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  Data: <searchLink fieldCode="AU" term="%22Wintermark+P%22">Wintermark P</searchLink>; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada. Electronic address: pia.wintermark@gmail.com.<br /><searchLink fieldCode="AU" term="%22Lapointe+A%22">Lapointe A</searchLink>; Division of Neonatology, Sainte-Justine Hospital, University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Altit+G%22">Altit G</searchLink>; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Steinhorn+R%22">Steinhorn R</searchLink>; Department of Pediatrics, Rady Children's Hospital and University of California San Diego, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Rampakakis+E%22">Rampakakis E</searchLink>; Department of Pediatrics, McGill University, Montreal, Canada; JSS Medical Research, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Meid+AD%22">Meid AD</searchLink>; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Burhenne+J%22">Burhenne J</searchLink>; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bajraktari-Sylejmani+G%22">Bajraktari-Sylejmani G</searchLink>; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Khairy+M%22">Khairy M</searchLink>; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Adamo+MT%22">Adamo MT</searchLink>; Pharmacy Department, McGill University Health Centre, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Gilbert+G%22">Gilbert G</searchLink>; MR Clinical Science, Philips Healthcare, Mississauga, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Toffoli+D%22">Toffoli D</searchLink>; Department of Ophthalmology, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Zavalkoff+S%22">Zavalkoff S</searchLink>; Research Institute of the McGill University Health Centre, McGill University, Montreal, Canada; Division of Pediatric Critical Care Medicine, Department of Pediatrics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Luu+TM%22">Luu TM</searchLink>; Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Hailu+E%22">Hailu E</searchLink>; Division of Neonatal Medicine and Follow-Up, Department of Pediatrics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Haefeli+WE%22">Haefeli WE</searchLink>; Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
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  Data: <searchLink fieldCode="JN" term="%220375410%22">The Journal of pediatrics</searchLink> [J Pediatr] 2025 Oct; Vol. 285, pp. 114701. <i>Date of Electronic Publication: </i>2025 Jun 23.
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      – TitleFull: Testing Higher Doses of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia: An Open-Label Dose-Finding Phase 1b Clinical Trial-Sildenafil Administration to Treat Neonatal Encephalopathy-Study 02.
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