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Severe toxicity and poor efficacy of reinduction chemotherapy are associated with overall poor outcomes in relapsed B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group AALL1331 trial.

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Title: Severe toxicity and poor efficacy of reinduction chemotherapy are associated with overall poor outcomes in relapsed B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group AALL1331 trial.
Authors: Hogan LE; Department of Pediatrics, Stony Brook Children's, Stony Brook, NY. laura.hogan@stonybrookmedicine.edu., Bhatla T; Children's Hospital of New Jersey at Newark Beth Israel, Newark, NJ., Xu X; Children's Oncology Group, Monrovia, CA., Gore L; University of Colorado School of Medicine and Center for Cancer and Blood Disorders, Children's Hospital of Colorado, Aurora, CO., Raetz EA; Department of Pediatrics, NYU Langone Health, New York, NY., Bhojwani D; Division of Hematology-Oncology, Children's Hospital Los Angeles, and Keck School of Medicine, University of Southern California, Los Angeles, CA., Teachey DT; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Hunger SP; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Loh ML; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, and the Department of Pediatrics, Seattle Children's Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA., Brown PA; Bristol Myers Squibb, Princeton, NJ., Ji L; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Source: Haematologica [Haematologica] 2025 Dec 01; Vol. 110 (12), pp. 2930-2941. Date of Electronic Publication: 2025 Jun 26.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Severe toxicity and poor efficacy of reinduction chemotherapy are associated with overall poor outcomes in relapsed B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group AALL1331 trial.
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  Data: <searchLink fieldCode="AU" term="%22Hogan+LE%22">Hogan LE</searchLink>; Department of Pediatrics, Stony Brook Children's, Stony Brook, NY. laura.hogan@stonybrookmedicine.edu.<br /><searchLink fieldCode="AU" term="%22Bhatla+T%22">Bhatla T</searchLink>; Children's Hospital of New Jersey at Newark Beth Israel, Newark, NJ.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Children's Oncology Group, Monrovia, CA.<br /><searchLink fieldCode="AU" term="%22Gore+L%22">Gore L</searchLink>; University of Colorado School of Medicine and Center for Cancer and Blood Disorders, Children's Hospital of Colorado, Aurora, CO.<br /><searchLink fieldCode="AU" term="%22Raetz+EA%22">Raetz EA</searchLink>; Department of Pediatrics, NYU Langone Health, New York, NY.<br /><searchLink fieldCode="AU" term="%22Bhojwani+D%22">Bhojwani D</searchLink>; Division of Hematology-Oncology, Children's Hospital Los Angeles, and Keck School of Medicine, University of Southern California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Teachey+DT%22">Teachey DT</searchLink>; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Hunger+SP%22">Hunger SP</searchLink>; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Loh+ML%22">Loh ML</searchLink>; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, and the Department of Pediatrics, Seattle Children's Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Brown+PA%22">Brown PA</searchLink>; Bristol Myers Squibb, Princeton, NJ.<br /><searchLink fieldCode="AU" term="%22Ji+L%22">Ji L</searchLink>; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
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  Data: <searchLink fieldCode="JN" term="%220417435%22">Haematologica</searchLink> [Haematologica] 2025 Dec 01; Vol. 110 (12), pp. 2930-2941. <i>Date of Electronic Publication: </i>2025 Jun 26.
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  Data: Journal Article; Randomized Controlled Trial; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE
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        Value: 10.3324/haematol.2025.287386
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        Text: English
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              Text: 2025 Dec 01
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