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Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.

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Title: Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.
Authors: Herold F; Department of Physiology, Faculty of Medicine, HMU Health and Medical University Erfurt, Erfurt, Germany.; Institute of Interdisciplinary Exercise Science and Sports Medicine, MSH Medical School Hamburg, Am Kaiserkai 1, 20457, Hamburg, Germany.; Research Group Degenerative and Chronic Diseases, Movement, Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany., Zou L; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China., Theobald P; Research Group Degenerative and Chronic Diseases, Movement, Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany., Manser P; Motor Control and Learning Group, Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland.; Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden., Falck RS; School of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada.; Aging, Mobility, and Cognitive Health Laboratory, Department of Physical Therapy, The University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Aging Solutions for Mobility, Activity, Rehabilitation and Technology (SMART) at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Yu Q; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China., Liu-Ambrose T; Aging, Mobility, and Cognitive Health Laboratory, Department of Physical Therapy, The University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Aging Solutions for Mobility, Activity, Rehabilitation and Technology (SMART) at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Kramer AF; Center for Cognitive and Brain Health, Northeastern University, Boston, MA, USA.; Department of Psychology, Northeastern University, Boston, MA, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Erickson KI; Department of Neuroscience, AdventHealth Research Institute, AdventHealth, Orlando, FL, USA.; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA., Cheval B; Department of Sport Sciences and Physical Education, Ecole Normale Supérieure Rennes, Bruz, France.; Laboratory VIPS2, University of Rennes, Rennes, France., Chen Y; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China., Heath M; School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, ON, N6A 3K7, Canada.; Canadian Centre for Activity and Aging, University of Western Ontario, London, ON, N6A 3K7, Canada.; Graduate Program in Neuroscience, University of Western Ontario, London, ON, N6A 3K7, Canada., Zhang Z; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China., Ishihara T; Graduate School of Human Development and Environment, Kobe University, Kobe, Japan., Kamijo K; Faculty of Liberal Arts and Sciences, Chukyo University, Nagoya, Japan., Ando S; Graduate School of Informatics and Engineering, The University of Electro-Communications, Tokyo, Japan., Costello JT; Extreme Environments Laboratory, School of Psychology, Sport and Health Sciences, University of Portsmouth, Portsmouth, UK., Hallgren M; Epidemiology of Psychiatric Conditions, Substance Use and Social Environment (EPiCSS), Department of Public Health Sciences, Karolinska Institute, Solna, Sweden.; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia., Moreau D; School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand., Farrahi V; Institute for Sport and Sport Science, TU Dortmund University, Dortmund, Germany., Raichlen DA; Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Anthropology, University of Southern California, Los Angeles, CA, 90089, USA., Stamatakis E; Mackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, School of Health Sciences, University of Sydney, Sydney, NSW, Australia., Wheeler MJ; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.; Physical Activity Laboratory, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia., Owen N; Physical Activity Laboratory, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.; School of Health Sciences, Swinburne University of Technology, Melbourne, VIC, Australia., Ludyga S; Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland., Budde H; Institute for Systems Medicine (ISM), MSH Medical School Hamburg, Hamburg, Germany., Gronwald T; Institute of Interdisciplinary Exercise Science and Sports Medicine, MSH Medical School Hamburg, Am Kaiserkai 1, 20457, Hamburg, Germany. Thomas.Gronwald@medicalschool-hamburg.de.; G-Lab, Faculty of Applied Sport Sciences and Personality, BSP Business and Law School, Berlin, Germany. Thomas.Gronwald@medicalschool-hamburg.de.
Source: European journal of applied physiology [Eur J Appl Physiol] 2025 Oct; Vol. 125 (10), pp. 2679-2707. Date of Electronic Publication: 2025 Jun 26.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 100954790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-6327 (Electronic) Linking ISSN: 14396319 NLM ISO Abbreviation: Eur J Appl Physiol Subsets: MEDLINE
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  Data: Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.
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  Data: <searchLink fieldCode="AU" term="%22Herold+F%22">Herold F</searchLink>; Department of Physiology, Faculty of Medicine, HMU Health and Medical University Erfurt, Erfurt, Germany.; Institute of Interdisciplinary Exercise Science and Sports Medicine, MSH Medical School Hamburg, Am Kaiserkai 1, 20457, Hamburg, Germany.; Research Group Degenerative and Chronic Diseases, Movement, Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Zou+L%22">Zou L</searchLink>; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Theobald+P%22">Theobald P</searchLink>; Research Group Degenerative and Chronic Diseases, Movement, Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Manser+P%22">Manser P</searchLink>; Motor Control and Learning Group, Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland.; Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Falck+RS%22">Falck RS</searchLink>; School of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada.; Aging, Mobility, and Cognitive Health Laboratory, Department of Physical Therapy, The University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Aging Solutions for Mobility, Activity, Rehabilitation and Technology (SMART) at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Liu-Ambrose+T%22">Liu-Ambrose T</searchLink>; Aging, Mobility, and Cognitive Health Laboratory, Department of Physical Therapy, The University of British Columbia, Vancouver, BC, Canada.; Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Centre for Aging Solutions for Mobility, Activity, Rehabilitation and Technology (SMART) at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Kramer+AF%22">Kramer AF</searchLink>; Center for Cognitive and Brain Health, Northeastern University, Boston, MA, USA.; Department of Psychology, Northeastern University, Boston, MA, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Erickson+KI%22">Erickson KI</searchLink>; Department of Neuroscience, AdventHealth Research Institute, AdventHealth, Orlando, FL, USA.; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cheval+B%22">Cheval B</searchLink>; Department of Sport Sciences and Physical Education, Ecole Normale Supérieure Rennes, Bruz, France.; Laboratory VIPS2, University of Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Heath+M%22">Heath M</searchLink>; School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, ON, N6A 3K7, Canada.; Canadian Centre for Activity and Aging, University of Western Ontario, London, ON, N6A 3K7, Canada.; Graduate Program in Neuroscience, University of Western Ontario, London, ON, N6A 3K7, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Body-Brain-Mind Laboratory, Shenzhen University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Ishihara+T%22">Ishihara T</searchLink>; Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Kamijo+K%22">Kamijo K</searchLink>; Faculty of Liberal Arts and Sciences, Chukyo University, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Ando+S%22">Ando S</searchLink>; Graduate School of Informatics and Engineering, The University of Electro-Communications, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Costello+JT%22">Costello JT</searchLink>; Extreme Environments Laboratory, School of Psychology, Sport and Health Sciences, University of Portsmouth, Portsmouth, UK.<br /><searchLink fieldCode="AU" term="%22Hallgren+M%22">Hallgren M</searchLink>; Epidemiology of Psychiatric Conditions, Substance Use and Social Environment (EPiCSS), Department of Public Health Sciences, Karolinska Institute, Solna, Sweden.; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Moreau+D%22">Moreau D</searchLink>; School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Farrahi+V%22">Farrahi V</searchLink>; Institute for Sport and Sport Science, TU Dortmund University, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Raichlen+DA%22">Raichlen DA</searchLink>; Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Anthropology, University of Southern California, Los Angeles, CA, 90089, USA.<br /><searchLink fieldCode="AU" term="%22Stamatakis+E%22">Stamatakis E</searchLink>; Mackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, School of Health Sciences, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wheeler+MJ%22">Wheeler MJ</searchLink>; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.; Physical Activity Laboratory, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Owen+N%22">Owen N</searchLink>; Physical Activity Laboratory, Baker Heart & Diabetes Institute, Melbourne, VIC, Australia.; School of Health Sciences, Swinburne University of Technology, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ludyga+S%22">Ludyga S</searchLink>; Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Budde+H%22">Budde H</searchLink>; Institute for Systems Medicine (ISM), MSH Medical School Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gronwald+T%22">Gronwald T</searchLink>; Institute of Interdisciplinary Exercise Science and Sports Medicine, MSH Medical School Hamburg, Am Kaiserkai 1, 20457, Hamburg, Germany. Thomas.Gronwald@medicalschool-hamburg.de.; G-Lab, Faculty of Applied Sport Sciences and Personality, BSP Business and Law School, Berlin, Germany. Thomas.Gronwald@medicalschool-hamburg.de.
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