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An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholesterolemia: Results of a Pilot Randomized Clinical Trial.

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Title: An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholesterolemia: Results of a Pilot Randomized Clinical Trial.
Authors: de Abreu-Silva EO; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.; Division of Health Care Sciences, Dresden International University, 01307 Dresden, Germany., Machado RHV; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Dos Santos BR; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Kojima FCS; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Santos RHN; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Negrelli KDL; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Rodrigues LB; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., de Barros E Silva PGM; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., de Lima AG; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Sanchez JG; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., El Khouri FJ; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Bersch-Ferreira ÂC; Department of Education and Research, BP-A Beneficência Portuguesa de São Paulo, São Paulo 01323-001, SP, Brazil., Carvalho AB; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil.; National Institute of Cardiology, Rio de Janeiro 22240-006, RJ, Brazil., de Oliveira TM; Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil., Izar MC; Paulista School of Medicine, Federal University of São Paulo, São Paulo 04024-002, SP, Brazil., Sampaio GR; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil., Damasceno NRT; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil., Rogero MM; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil., Torres EAFDS; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil., Cartolano FC; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil., Krey JP; Hcor Nutrition Service, São Paulo 04004-030, SP, Brazil., de Luca PV; Brazilian Association of Familial Hypercholesterolemia, São Paulo 04044-903, SP, Brazil., Amaral CK; Ambulatório de Nutrição Clínica, Instituto Dante Pazzanese de Cardiologia, São Paulo 04012-180, SP, Brazil., Dos Santos EM; Graduate Program in Cardiovascular Sciences, National Institute of Cardiology, Rio de Janeiro 22240-006, RJ, Brazil., de Melo RMV; Graduate Program in Medicine and Health, Federal University of Bahia, Salvador 40026-010, BA, Brazil.; Hospital Ana Nery, Salvador 40320-010, BA, Brazil., Lima EG; Atherosclerosis Clinical Unit, Hospital das Clínicas Heart Institute, School of Medicine, University of São Paulo, São Paulo 05403-000, SP, Brazil.; Dasa Cardiology Unit (Hospital 9 de Julho), São Paulo 01409-002, SP, Brazil., Dos Santos AL; Clinical Research Center, Hospital São José, Criciúma 88811-500, SC, Brazil., Heck TG; Graduate Programs in Integral Health Care and in Mathematical and Computational Modeling, Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ), Ijuí 98700-000, RS, Brazil., Carvalho APPF; Hypertension Unit and Health and Nutrition Research Improvement Group, Clinical Hospital, Federal University of Goiás, Goiânia 74605-020, GO, Brazil., Garofallo SB; Graduate Program in Health Sciences (Cardiology), Rio Grande do Sul Cardiology Institute, University Foundation of Cardiology, Porto Alegre 90040-371, RS, Brazil.; School of Medicine, Feevale University, Novo Hamburgo 93510-235, RS, Brazil., Cavalcanti AB; Hcor Research Institute, São Paulo 04004-030, SP, Brazil., Marcadenti A; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.; Graduate Program in Health Sciences (Cardiology), Rio Grande do Sul Cardiology Institute, University Foundation of Cardiology, Porto Alegre 90040-371, RS, Brazil.; Graduate Program in Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil.
Source: Nutrients [Nutrients] 2025 Jun 15; Vol. 17 (12). Date of Electronic Publication: 2025 Jun 15.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholesterolemia: Results of a Pilot Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22de+Abreu-Silva+EO%22">de Abreu-Silva EO</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.; Division of Health Care Sciences, Dresden International University, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Machado+RHV%22">Machado RHV</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+BR%22">Dos Santos BR</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Kojima+FCS%22">Kojima FCS</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+RHN%22">Santos RHN</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Negrelli+KDL%22">Negrelli KDL</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+LB%22">Rodrigues LB</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Barros+E+Silva+PGM%22">de Barros E Silva PGM</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Lima+AG%22">de Lima AG</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Sanchez+JG%22">Sanchez JG</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22El+Khouri+FJ%22">El Khouri FJ</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Bersch-Ferreira+ÂC%22">Bersch-Ferreira ÂC</searchLink>; Department of Education and Research, BP-A Beneficência Portuguesa de São Paulo, São Paulo 01323-001, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Carvalho+AB%22">Carvalho AB</searchLink>; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil.; National Institute of Cardiology, Rio de Janeiro 22240-006, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+TM%22">de Oliveira TM</searchLink>; Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Izar+MC%22">Izar MC</searchLink>; Paulista School of Medicine, Federal University of São Paulo, São Paulo 04024-002, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Sampaio+GR%22">Sampaio GR</searchLink>; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Damasceno+NRT%22">Damasceno NRT</searchLink>; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Rogero+MM%22">Rogero MM</searchLink>; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Torres+EAFDS%22">Torres EAFDS</searchLink>; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Cartolano+FC%22">Cartolano FC</searchLink>; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Krey+JP%22">Krey JP</searchLink>; Hcor Nutrition Service, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Luca+PV%22">de Luca PV</searchLink>; Brazilian Association of Familial Hypercholesterolemia, São Paulo 04044-903, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Amaral+CK%22">Amaral CK</searchLink>; Ambulatório de Nutrição Clínica, Instituto Dante Pazzanese de Cardiologia, São Paulo 04012-180, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+EM%22">Dos Santos EM</searchLink>; Graduate Program in Cardiovascular Sciences, National Institute of Cardiology, Rio de Janeiro 22240-006, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Melo+RMV%22">de Melo RMV</searchLink>; Graduate Program in Medicine and Health, Federal University of Bahia, Salvador 40026-010, BA, Brazil.; Hospital Ana Nery, Salvador 40320-010, BA, Brazil.<br /><searchLink fieldCode="AU" term="%22Lima+EG%22">Lima EG</searchLink>; Atherosclerosis Clinical Unit, Hospital das Clínicas Heart Institute, School of Medicine, University of São Paulo, São Paulo 05403-000, SP, Brazil.; Dasa Cardiology Unit (Hospital 9 de Julho), São Paulo 01409-002, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+AL%22">Dos Santos AL</searchLink>; Clinical Research Center, Hospital São José, Criciúma 88811-500, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Heck+TG%22">Heck TG</searchLink>; Graduate Programs in Integral Health Care and in Mathematical and Computational Modeling, Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ), Ijuí 98700-000, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Carvalho+APPF%22">Carvalho APPF</searchLink>; Hypertension Unit and Health and Nutrition Research Improvement Group, Clinical Hospital, Federal University of Goiás, Goiânia 74605-020, GO, Brazil.<br /><searchLink fieldCode="AU" term="%22Garofallo+SB%22">Garofallo SB</searchLink>; Graduate Program in Health Sciences (Cardiology), Rio Grande do Sul Cardiology Institute, University Foundation of Cardiology, Porto Alegre 90040-371, RS, Brazil.; School of Medicine, Feevale University, Novo Hamburgo 93510-235, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Cavalcanti+AB%22">Cavalcanti AB</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Marcadenti+A%22">Marcadenti A</searchLink>; Hcor Research Institute, São Paulo 04004-030, SP, Brazil.; Graduate Program in Health Sciences (Cardiology), Rio Grande do Sul Cardiology Institute, University Foundation of Cardiology, Porto Alegre 90040-371, RS, Brazil.; Graduate Program in Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101521595%22">Nutrients</searchLink> [Nutrients] 2025 Jun 15; Vol. 17 (12). <i>Date of Electronic Publication: </i>2025 Jun 15.
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