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Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia.

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Title: Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia.
Authors: Costea J; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Rauwolf KK; Division of Pediatric Oncology, University Children's Hospital, Zürich, Switzerland., Zafferani P; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Molecular Biosciences/Cancer Biology Program, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Rausch T; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genomics Core Facility, Heidelberg, Germany., Mathioudaki A; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory, Molecular Systems Biology Unit, Heidelberg, Germany.; Artificial Intelligence in Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Zaugg J; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory, Molecular Systems Biology Unit, Heidelberg, Germany., Schrappe M; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Eckert C; Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Escherich G; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bourquin JP; Division of Pediatric Oncology, University Children's Hospital, Zürich, Switzerland., Bornhauser B; Division of Pediatric Oncology, University Children's Hospital, Zürich, Switzerland., Kulozik AE; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Hopp Children's Cancer Center (KiTZ) Heidelberg, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ), Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de., Korbel JO; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany. jan.korbel@embl.de.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany. jan.korbel@embl.de.; Bridging Research Division on Mechanisms of Genomic Variation and Data Science, German Cancer Research Center (DKFZ), Heidelberg, Germany. jan.korbel@embl.de.
Source: Nature communications [Nat Commun] 2025 Jun 27; Vol. 16 (1), pp. 5413. Date of Electronic Publication: 2025 Jun 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Costea+J%22">Costea J</searchLink>; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rauwolf+KK%22">Rauwolf KK</searchLink>; Division of Pediatric Oncology, University Children's Hospital, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zafferani+P%22">Zafferani P</searchLink>; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Molecular Biosciences/Cancer Biology Program, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rausch+T%22">Rausch T</searchLink>; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Genomics Core Facility, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mathioudaki+A%22">Mathioudaki A</searchLink>; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory, Molecular Systems Biology Unit, Heidelberg, Germany.; Artificial Intelligence in Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zaugg+J%22">Zaugg J</searchLink>; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany.; European Molecular Biology Laboratory, Molecular Systems Biology Unit, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schrappe+M%22">Schrappe M</searchLink>; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Eckert+C%22">Eckert C</searchLink>; Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Escherich+G%22">Escherich G</searchLink>; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bourquin+JP%22">Bourquin JP</searchLink>; Division of Pediatric Oncology, University Children's Hospital, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; Division of Pediatric Oncology, University Children's Hospital, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kulozik+AE%22">Kulozik AE</searchLink>; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Hopp Children's Cancer Center (KiTZ) Heidelberg, Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ), Heidelberg, Germany. andreas.kulozik@med.uni-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Korbel+JO%22">Korbel JO</searchLink>; Molecular Medicine Partnership Unit (MMPU), EMBL and Medical Faculty of Heidelberg University, Heidelberg, Germany. jan.korbel@embl.de.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany. jan.korbel@embl.de.; Bridging Research Division on Mechanisms of Genomic Variation and Data Science, German Cancer Research Center (DKFZ), Heidelberg, Germany. jan.korbel@embl.de.
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