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Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features.

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Title: Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features.
Authors: Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zeng AGX; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Gao Q; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Garcia-Prat L; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Baviskar P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Shah S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Murison A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Voisin V; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Chan-Seng-Yue M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Cheng C; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Qu C; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Bailey C; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Lear M; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Witkowski MT; Department of Pediatrics-HemeOnc and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zaldivar Peraza A; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gangwani K; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Advani AS; Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA., Luger SM; Abramson Cancer Center and the Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA., Litzow MR; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Rowe JM; Rambam Health Care Campus and Technion, Israel Institute of Technology, Haifa, Israel.; Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel., Paietta EM; Department of Oncology, Montefiore Medical Center, Bronx, NY, USA., Stock W; Hematopoiesis and Hematological Malignancies Program, University of Chicago, Chicago, IL, USA., Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. john.dick@uhn.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. john.dick@uhn.ca., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.; Center of Excellence for Leukemia Studies, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.
Source: Nature cancer [Nat Cancer] 2025 Jul; Vol. 6 (7), pp. 1242-1262. Date of Electronic Publication: 2025 Jun 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features.
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  Data: <searchLink fieldCode="AU" term="%22Iacobucci+I%22">Iacobucci I</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+AGX%22">Zeng AGX</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Prat+L%22">Garcia-Prat L</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Baviskar+P%22">Baviskar P</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shah+S%22">Shah S</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Murison+A%22">Murison A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Voisin+V%22">Voisin V</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chan-Seng-Yue+M%22">Chan-Seng-Yue M</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cheng+C%22">Cheng C</searchLink>; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Qu+C%22">Qu C</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bailey+C%22">Bailey C</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lear+M%22">Lear M</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Witkowski+MT%22">Witkowski MT</searchLink>; Department of Pediatrics-HemeOnc and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Zaldivar+Peraza+A%22">Zaldivar Peraza A</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gangwani+K%22">Gangwani K</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Advani+AS%22">Advani AS</searchLink>; Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Luger+SM%22">Luger SM</searchLink>; Abramson Cancer Center and the Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Litzow+MR%22">Litzow MR</searchLink>; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Rowe+JM%22">Rowe JM</searchLink>; Rambam Health Care Campus and Technion, Israel Institute of Technology, Haifa, Israel.; Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Paietta+EM%22">Paietta EM</searchLink>; Department of Oncology, Montefiore Medical Center, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stock+W%22">Stock W</searchLink>; Hematopoiesis and Hematological Malignancies Program, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Dick+JE%22">Dick JE</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. john.dick@uhn.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. john.dick@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Mullighan+CG%22">Mullighan CG</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.; Center of Excellence for Leukemia Studies, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2025 Jul; Vol. 6 (7), pp. 1242-1262. <i>Date of Electronic Publication: </i>2025 Jun 27.
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