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Phase 1 study of zavondemstat (TACH101), a first-in-class KDM4 inhibitor, in patients with advanced solid tumors.

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Title: Phase 1 study of zavondemstat (TACH101), a first-in-class KDM4 inhibitor, in patients with advanced solid tumors.
Authors: Tsimberidou AM; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dayyani F; Chao Family Comprehensive Cancer Center, University of California at Irvine, Orange, CA, USA., Sommerhalder D; NEXT Oncology, San Antonio, TX, USA., Vandross AL; NEXT Oncology, Austin, TX, USA., Pelster MS; Sarah Cannon Research Institute, Nashville, TN, USA., Henry JT; Sarah Cannon Research Institute at HealthONE, Denver, CO, USA., Perez CA; Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, FL, USA., Chakraborty A; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Baysal MA; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chandhasin C; Tachyon Therapeutics Inc., San Francisco, CA, USA., Dai Y; Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, FL, USA., Tu S; Tachyon Therapeutics Inc., San Francisco, CA, USA., King I; Tachyon Therapeutics Inc., San Francisco, CA, USA., Perabo F; Tachyon Therapeutics Inc., San Francisco, CA, USA.
Source: The oncologist [Oncologist] 2025 Jul 04; Vol. 30 (7).
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9607837 Publication Model: Print Cited Medium: Internet ISSN: 1549-490X (Electronic) Linking ISSN: 10837159 NLM ISO Abbreviation: Oncologist Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase 1 study of zavondemstat (TACH101), a first-in-class KDM4 inhibitor, in patients with advanced solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Tsimberidou+AM%22">Tsimberidou AM</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dayyani+F%22">Dayyani F</searchLink>; Chao Family Comprehensive Cancer Center, University of California at Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sommerhalder+D%22">Sommerhalder D</searchLink>; NEXT Oncology, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vandross+AL%22">Vandross AL</searchLink>; NEXT Oncology, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Pelster+MS%22">Pelster MS</searchLink>; Sarah Cannon Research Institute, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Henry+JT%22">Henry JT</searchLink>; Sarah Cannon Research Institute at HealthONE, Denver, CO, USA.<br /><searchLink fieldCode="AU" term="%22Perez+CA%22">Perez CA</searchLink>; Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Chakraborty+A%22">Chakraborty A</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Baysal+MA%22">Baysal MA</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chandhasin+C%22">Chandhasin C</searchLink>; Tachyon Therapeutics Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dai+Y%22">Dai Y</searchLink>; Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Tu+S%22">Tu S</searchLink>; Tachyon Therapeutics Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22King+I%22">King I</searchLink>; Tachyon Therapeutics Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Perabo+F%22">Perabo F</searchLink>; Tachyon Therapeutics Inc., San Francisco, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%229607837%22">The oncologist</searchLink> [Oncologist] 2025 Jul 04; Vol. 30 (7).
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  Data: Journal Article; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607837 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1549-490X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210837159%22">10837159 </searchLink><i>NLM ISO Abbreviation: </i>Oncologist <i>Subsets: </i>MEDLINE
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        Value: 10.1093/oncolo/oyaf169
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        Text: English
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              Text: 2025 Jul 04
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