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The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA.

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Title: The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA.
Authors: Rabinowitz J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Vila IK; IGMM, Université de Montpellier, CNRS, Montpellier, France., Luchsinger C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Bertelli C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Schüssler M; IGMM, Université de Montpellier, CNRS, Montpellier, France., Taffoni C; IGMM, Université de Montpellier, CNRS, Montpellier, France., Cui B; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Dai AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Rashid MM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Cisneros WJ; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Cornish D; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Redondo J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Jackson-Jones KA; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Simons LM; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Lorenzo-Redondo R; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Laguette N; IGMM, Université de Montpellier, CNRS, Montpellier, France., Hultquist JF; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Diaz-Griffero F; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: Felipe.Diaz-Griffero@einsteinmed.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Aug; Vol. 301 (8), pp. 110430. Date of Electronic Publication: 2025 Jun 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Aug; Vol. 301 (8), pp. 110430. <i>Date of Electronic Publication: </i>2025 Jun 26.
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