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Sex-based differences in ICU management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort.

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Title: Sex-based differences in ICU management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort.
Authors: Mehta S; Department of Medicine, Sinai Health System, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: geeta.mehta@utoronto.ca., Azoulay E; Medecine Intensive et Réanimation, AP-HP, Hôpital Saint-Louis, Paris, France; Université Paris Cité, Paris, France; ICU-People Research Team, INSERM 1342, Institut de Recherche Saint-Louis, Paris, France., Munshi L; Department of Medicine, Sinai Health System, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada., Demoule A; AP-HP. Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Médecine intensive - Réanimation (Département 'R3S') and Sorbonne Université, INSERM, UMRS1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France., Perner A; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Meyhoff TS; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Denmark., Bauer PR; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA., Metaxa V; Department of Critical Care, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK; Centre for Education, Faculty of Life Sciences & Medicine, King's College London, Strand, London WC2R 2LS, UK., Pène F; Université Paris Cité, Assistance Publique - Hôpitaux de Paris, Hôpital Cochin, DMU Réanimation-Urgences, Service de Médecine Intensive Réanimation, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France., Girault C; Medical Intensive Care Unit, CHU Rouen, and Univ Rouen Normandie, Normandie Univ, GRHVN-UR 3830, F-76000 Rouen, France., Soares M; Department of Critical Care and Postgraduate Program, D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Taccone FS; Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium., Antonelli M; Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy., Barbier F; Medical Intensive Care Unit, La Source Hospital, CHR Orléans, Orléans, France., Barratt-Due A; Department of Anesthesia and Intensive Care, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway., Bruneel F; Medecine Intensive et Reanimation, Centre Hospitalier de Versailles, Hopital Mignot, 78150 Le Chesnay Rocquencourt, France., Bukan RB; Department of Anesthesiology, Herlev University Hospital, Herlev, Denmark., Burghi G; Intensive Care Unit, Hospital Maciel, Montevideo, Uruguay., Chevret S; UMR 1153 CRESS, Biostatistics and Clinical Epidemiology Research Team, Université Paris Cité, Paris, France., Gaborit B; Department of Infectious Diseases, University Hospital of Nantes and Centre d'Investigation Clinique 1413, INSERM, Nantes, France., Hemelaar P; Radboud University Medical Center, Department of Intensive Care Medicine, Nijmegen, the Netherlands., Kouatchet A; Department of Medical Intensive Care Medicine, University Hospital of Angers, Angers, France., Landburg PP; Department of Critical Care, University Medical Center Groningen, Groningen, the Netherlands., Lemiale V; Saint Louis Hospital, 1 avenue Claude Vellefaux, Paris, France., Martin-Loeches I; Trinity College Dublin, School of Medicine, Dublin, Ireland., Mokart D; Département d'Anesthésie-Réanimation, Institut Paoli-Calmettes, Marseilles, France., Moreau AS; Médecine Intensive et Réanimation, Centre Hospitalier Universitaire de Lille, Lille, France., Montini L; Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy., Nielsen LB; Department of Anesthesiology and Intensive Care, Odense University hospital, Odense, Denmark., Pickkers P; The Department of Intensive Care Medicine (710), Radboud University Medical Center, Nijmegen, the Netherlands., Rello J; IMAGINE, UR-UM 107, University of Montpellier, Division of Anaesthesia Critical Care, Pain and Emergency Medicine, Nîmes University Hospital, Nîmes, France; Medicine Department, Universitat Internacional de Catalunya, Spain; Clinical Research Pneumonia and Sepsis (CRIPS) Research Group-Vall d'Hebron Institute Research (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos III, Madrid, Spain., Rusinova K; Department of Anesthesiology and Intensive Care Medicine and Institute for Medical Humanities, 1st Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic., Salluh J; Department of Critical Care and Postgraduate Program in Translational Medicine, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil., Schellongowski P; Department of Medicine I, Medical University of Vienna, Vienna, Austria., Souppart V; Medical Intensive Care Unit, Famiréa Research Group, APHP, Saint Louis University Hospital, Paris, France., Terzi N; Medical Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France; Medical Intensive Care Unit, University Hospital of Rennes, Rennes, France., Valkonen M; Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland., van de Louw A; Division of Pulmonary and Critical Care Medicine, Penn State Health Milton Hershey Medical Center, Hershey, PA 17036, USA., Darmon M; Medecine Intensive et Réanimation, AP-HP, Hôpital Saint-Louis, Paris, France.
Corporate Authors: Efraim investigators and the Nine-I study group
Source: Journal of critical care [J Crit Care] 2025 Oct; Vol. 89, pp. 155149. Date of Electronic Publication: 2025 Jun 28.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8610642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8615 (Electronic) Linking ISSN: 08839441 NLM ISO Abbreviation: J Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mehta+S%22">Mehta S</searchLink>; Department of Medicine, Sinai Health System, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: geeta.mehta@utoronto.ca.<br /><searchLink fieldCode="AU" term="%22Azoulay+E%22">Azoulay E</searchLink>; Medecine Intensive et Réanimation, AP-HP, Hôpital Saint-Louis, Paris, France; Université Paris Cité, Paris, France; ICU-People Research Team, INSERM 1342, Institut de Recherche Saint-Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Munshi+L%22">Munshi L</searchLink>; Department of Medicine, Sinai Health System, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Demoule+A%22">Demoule A</searchLink>; AP-HP. Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Médecine intensive - Réanimation (Département 'R3S') and Sorbonne Université, INSERM, UMRS1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France.<br /><searchLink fieldCode="AU" term="%22Perner+A%22">Perner A</searchLink>; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Meyhoff+TS%22">Meyhoff TS</searchLink>; Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Denmark.<br /><searchLink fieldCode="AU" term="%22Bauer+PR%22">Bauer PR</searchLink>; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Metaxa+V%22">Metaxa V</searchLink>; Department of Critical Care, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK; Centre for Education, Faculty of Life Sciences & Medicine, King's College London, Strand, London WC2R 2LS, UK.<br /><searchLink fieldCode="AU" term="%22Pène+F%22">Pène F</searchLink>; Université Paris Cité, Assistance Publique - Hôpitaux de Paris, Hôpital Cochin, DMU Réanimation-Urgences, Service de Médecine Intensive Réanimation, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.<br /><searchLink fieldCode="AU" term="%22Girault+C%22">Girault C</searchLink>; Medical Intensive Care Unit, CHU Rouen, and Univ Rouen Normandie, Normandie Univ, GRHVN-UR 3830, F-76000 Rouen, France.<br /><searchLink fieldCode="AU" term="%22Soares+M%22">Soares M</searchLink>; Department of Critical Care and Postgraduate Program, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Taccone+FS%22">Taccone FS</searchLink>; Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Antonelli+M%22">Antonelli M</searchLink>; Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Barbier+F%22">Barbier F</searchLink>; 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